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首页> 外文期刊>Clinics in dermatology >Cutaneous adverse drug reactions: Kids are not just little people
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Cutaneous adverse drug reactions: Kids are not just little people

机译：皮肤不良药物反应：孩子们不仅仅是小人物

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摘要

Abstract Cutaneous adverse drug reactions are a common complication of drug therapy and affect patients of all ages. Despite the daunting frequency at which these reactions occur, there are no scientific contributions comparing cutaneous adverse drug reactions in adults to those occurring in children. Literature delineating such differences is important given that there are significant age-related differences in the pharmacokinetics of many drugs and that most of the package-insert data on adverse drug reactions are based on preclinical trials that do not include children as participants. This contribution attempts to bridge the literature gap by examining five cutaneous adverse drug reactions that occur in both adults and children, highlighting the many types of age-related differences, with a special emphasis on comparisons of (1) epidemiology, (2) etiology, (3) clinical presentation, (4) workup, and (5) treatment.
机译：摘要皮肤不良药物反应是药物治疗的常见并发症，并影响所有年龄段的患者。 尽管发生了这些反应的令人生畏的频率，但没有科学贡献将成年人的皮肤不良药物与儿童发生的人进行比较。 划定这种差异的文献很重要，因为许多药物的药代动力学存在显着的年龄相关差异，并且大多数包装 - 插入关于不良药物反应的数据均基于临床前试验，这些试验不包括儿童作为参与者。 这一贡献试图通过检查成人和儿童中发生的五种皮肤不良药物反应来弥合文献差距，突出多种与年龄相关的差异，特别强调（1）流行病学，（2）病因， （3）临床介绍，（4）余处，（5）治疗。

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