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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Recurrent respiratory tract infections (RRTI) in the elderly: A late onset mild immunodeficiency?
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Recurrent respiratory tract infections (RRTI) in the elderly: A late onset mild immunodeficiency?

机译：老年人的经常性呼吸道感染（RRTI）：迟到的疾病轻度免疫缺陷？

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摘要

Elderly with late-onset recurrent respiratory tract infections (RRTI) often have specific anti-polysaccharide antibody deficiency (SPAD). We hypothesized that late-onset RRTI is caused by mild immunodeficiencies, such as SPAD, that remain hidden through adult life. We analyzed seventeen elderly RRTI patients and matched controls. We determined lymphocyte subsets, expression of BAFF receptors, serum immunoglobulins, complement pathways, Pneumovax-23 vaccination response and genetic variations in BAFFR and MBL2. Twelve patients (71%) and ten controls (59%) had SPAD. IgA was lower in patients than in controls, but other parameters did not differ. However, a high percentage of both patients (53%) and controls (65%) were MBL deficient, much more than in the general population. Often, MBL2 secretor genotypes did not match functional deficiency, suggesting that functional MBL deficiency can be an acquired condition. In conclusion, we found SPAD and MBL deficiency in many elderly, and conjecture that at least the latter arises with age. (C) 2017 Elsevier Inc. All rights reserved.
机译：老年人具有后期发作的反复性呼吸道感染（RRTI）通常具有特异性的抗多糖抗体缺乏（SPAD）。我们假设晚期rRTI是由温和免疫缺陷（例如SPAD）引起的，这仍然隐藏在成年生活中。我们分析了17名老年人RRTI患者和匹配的对照。我们确定了淋巴细胞亚群，表达BAFF受体，血清免疫球蛋白，补体途径，肺活量的疫苗接种响应和BAFFR和MBL2中的遗传变异。十二名患者（71％）和十种对照（59％）有Spad。患者的IgA较低，但在对照中较低，但其他参数没有差异。然而，两种患者（53％）和对照（65％）的高百分比是MBL的缺陷，远远超过一般人群。通常，MBL2分泌器基因型与功能缺乏不匹配，表明功能性MBL缺乏可以是所获得的条件。总之，我们发现了许多老年人的Spad和MBL缺乏，并猜测至少后者出现年龄。 （c）2017年Elsevier Inc.保留所有权利。

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