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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Contribution of VH replacement products to the generation of anti-HIV antibodies
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Contribution of VH replacement products to the generation of anti-HIV antibodies

机译：VH替代产品对抗HIV抗体产生的贡献

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Abstract VH replacement occurs through RAG-mediated secondary recombination to change unwanted IgH genes and diversify antibody repertoire. The biological significance of VH replacement remains to be explored. Here, we show that VH replacement products are highly enriched in IgH genes encoding anti-HIV antibodies, including anti-gp41, anti-V3 loop, anti-gp120, CD4i, and PGT antibodies. In particular, 73% of the CD4i antibodies and 100% of the PGT antibodies are encoded by potential VH replacement products. Such frequencies are significantly higher than those in IgH genes derived from HIV infected individuals or autoimmune patients. The identified VH replacement products encoding anti-HIV antibodies are highly mutated; the VH replacement "footprints" within CD4i antibodies preferentially encode negatively charged amino acids within the IgH CDR3; many IgH encoding PGT antibodies are likely generated from multiple rounds of VH replacement. Taken together, these findings uncovered a potentially significant contribution of VH replacement products to the generation of anti-HIV antibodies.
机译：摘要通过rag介导的二次重组发生vh替代，以改变不需要的异味基因和多样化抗体曲目。 VH更换的生物学意义仍有待探索。在这里，我们表明VH替代产品在编码抗HIV抗体的IGH基因中高度富集，包括抗GP41，抗V3环，抗GP120，CD4i和PGT抗体。特别地，73％的CD4i抗体和100％的PGT抗体通过潜在的VH替代产品编码。这种频率显着高于来自受HIV感染的个体或自身免疫患者的IGH基因的频率。编码抗HIV抗体的鉴定的VH替代产品高度突变; CD4i抗体内的VH替代“足迹”优先编码IGH CDR3内的带负电荷的氨基酸;许多编码PGT抗体可能从多轮VH更换中产生。在一起，这些发现发现了VH替代产品对抗HIV抗体产生的潜在显着贡献。

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