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首页> 外文期刊>Clinical colorectal cancer >Effect of Body Mass Index on 5-FU-Based Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer; A Pooled Analysis of 5 Randomized Trials
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Effect of Body Mass Index on 5-FU-Based Chemotherapy Toxicity and Efficacy Among Patients With Metastatic Colorectal Cancer; A Pooled Analysis of 5 Randomized Trials

机译：体重指数对转移结直肠癌患者5富基化疗毒性和功效的影响; 汇总分析5次随机试验

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摘要

We conducted a pooled analysis of 5 clinical trials to assess the effect of baseline body mass index (BMI) on the toxicity and efficacy of systemic chemotherapy among patients with metastatic colorectal cancer (CRC). Lower BMI was associated with a higher risk of hematological toxicities (anemia and neutropenia) whereas higher BMI was associated with a higher risk of nausea, vomiting, and peripheral neuropathy, and seemed to be associated with better overall survival among patients with metastatic CRC.
机译：我们对5项临床试验进行了汇总分析，以评估基线体重指数（BMI）对转移结直肠癌（CRC）患者毒性和疗效的影响。 较低的BMI与血液毒性毒性的风险更高（贫血和中性粒细胞病），而高度的BMI与恶心，呕吐和外周神经病变的风险较高，似乎与转移CRC患者的更好的整体存活有关。

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