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首页> 外文期刊>Clinical drug investigation >A Literature Review of Psychotropic Medications and Alcohol as Risk Factors for Falls in Community Dwelling Older Adults
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A Literature Review of Psychotropic Medications and Alcohol as Risk Factors for Falls in Community Dwelling Older Adults

机译：精神药物和酗酒的文献综述作为社区住宅年龄较大的成年人瀑布危险因素

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Psychotropic medications and alcohol are potential risk factors for falls in older adults. However, there has been no appraisal of the literature on whether these medications, both singly and in combination with alcohol, are associated with falls in community dwelling older adults (those aged 60years and older living independently without care). Four databases (PubMed, EMBASE, CINAHL and SCOPUS) and the grey literature (i.e. WHO, Public Health Agency of Canada) were searched using the following terms: benzodiazepine, anti-psychotics, anti-depressants, anti-epileptic, lithium, memantine, anti-hypertensives: drug or medication, aged or elderly or older adult or senior, accidental falls or falls or falling, and alcohol. Studies were included if (1) they were primary studies; (2) included community dwelling persons aged 60years and older; (3) alcohol use was an independent variable; (4) studiedmedications of interest; (5) falls was theoutcome variable; and (6) published in English. Articles published until July 2018 were included. The search yielded 29 studies. The findings show that both benzodiazepines and antidepressants (particularly SSRIs) are associated with fall risk while antipsychotics, anti-hypertensives, anti-epileptics and alcohol are not. No statements were made about lithium or memantine due to a lack of research studies. Future studies with adequate power to detect significant associations between psychotropic medications and falls are needed, especially among individual benzodiazepine and antidepressant medications.
机译：精神药物药物和酒精是老年人跌落的潜在危险因素。然而，无论这些药物是否与酒精相结合，都没有评估这些药物，与社区住宅年龄较大的成年人（60年龄和老年人独立而没有护理）有关。使用以下条款搜索四个数据库（PubMed，Embase，Cinahl和Scopus）和灰色文学（即加拿大的公共卫生机构）：苯二氮卓，抗精神病，抗抑郁症，抗癫痫，锂，留念，抗高血压：药物或药物，老年人或老年人或老年人或高级，意外落下或跌倒或跌倒，酒精。如果（1）他们是初级研究，则包括研究; （2）包括60岁及以上的社区住宅人员; （3）酒精使用是一个独立的变量; （4）研究感兴趣的境地; （5）跌倒是Theoutcome变量; （6）用英语发表。公布的文章于2018年7月出版。搜索产生29项研究。结果表明，苯并二氮杂卓和抗抑郁药（特别是SSRIS）与抗精神病药，抗高血压，抗癫痫症和酒精无关。由于缺乏研究研究，没有关于锂或想念的陈述。需要采用足够的力量来检测精神药物和跌倒之间的重要关联的研究，特别是在单个苯二氮卓和抗抑郁药物中。

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