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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Retrospective Analysis of Nonepileptic Patients With Isolated Epileptiform Discharges Treated With Anticonvulsants
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Retrospective Analysis of Nonepileptic Patients With Isolated Epileptiform Discharges Treated With Anticonvulsants

机译：用抗惊厥药处理分离癫痫患者非渗透患者的回顾性分析

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Many antiepileptic drugs (AEDs) have been tested on nonepileptic patients with a variety of diagnoses. The Food and Drug Administration has only approved certain AEDs for a small number of psychiatric conditions. There are few studies of nonepileptic patients that recommend an empirical trial of AEDs when isolated epileptiform discharges (IEDs) are identified in the electroencephalogram (EEG). However, no trials have been published. The purpose of this study is to evaluate the outcome of treating nonepileptic patients with AEDs when IEDs are present. Refractory cases were reviewed from a multidisciplinary practice whose EEG readings contained IEDs and were subsequently medicated with anticonvulsants by the clinic's psychiatrist. The psychiatrist's progress notes were assessed to determine the impact of adding anticonvulsants based on parent reports, teacher reports, and clinical observation. The final sample was composed of 76 refractory cases. Of the 76 patients treated with anticonvulsants, the majority were found to be improved in follow-up progress notes: 65 improved (85.53%), 6 unchanged (7.89%), and 5 more severe (6.58%). These observational findings suggest that further studies will be needed to show that IEDs may predict positive treatment outcome to anticonvulsant medication and act as a step toward an evidence-based treatment. Also, EEG screening may prove to be useful for refractory cases regardless of age, gender, or diagnosis.
机译：许多抗癫痫药物（AEDs）已经在非诊断患者上进行过患者进行测试。食品和药物管理局只批准了某些AED的少数精神病条件。对于在脑电图（EEG）中鉴定出分离的癫痫型排出（IED）时，似乎关于患有AED的经验试验的内部研究。但是，没有发表任何试验。本研究的目的是评估当IED存在时对患有AED患者治疗非患者的结果。从多学科实践中审查了耐火性案例，其EEG读数含有IED，随后被诊所的精神科医生用抗惊厥药用药。精神病医生的进展记录被评估，以确定添加抗惊厥药基于母公司报告，教师报告和临床观察的影响。最终样品由76个耐火性案例组成。在用抗惊厥药治疗的76名患者中，大多数人被发现在后续进展中得到改善：65种改善（85.53％），6个不变（7.89％），5次更严重（6.58％）。这些观察结果表明，将需要进一步的研究表明IED可能预测抗抑郁药物的阳性治疗结果，并作为朝向基于证据的待遇的措施。此外，脑电图筛查可能证明是可用于难治性案例，无论年龄，性别或诊断。

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