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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will Benefit From Sedatives in Improving Positive Airway Pressure Adherence in Sleep Apnea to 90%
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Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will Benefit From Sedatives in Improving Positive Airway Pressure Adherence in Sleep Apnea to 90%

机译：基线睡眠效率和唤醒指数不会预测谁将受益于镇静剂，从而改善睡眠呼吸暂停症的正气道压力粘附到90％

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Positive airway pressure (PAP) is the preferred treatment for obstructive sleep apnea (OSA), but adherence is low. Educational or ongoing supportive intervention improves the number of PAP adherent patients from the 50% to the 70% range. A common side effect of PAP is increased awakenings. This prospective trial examined baseline polysomnographically derived sleep efficiency and arousal index in PAP adherent and nonadherent patients, and in patients needing sedating medicines to attain PAP adherence versus those who did not need such medicines. Patients with OSA were titrated on PAP during a polysomnography or treated with autotitrating PAP, followed by educational and supportive interventions. Patients with PAP related awakenings (patients describing waking up and taking PAP off in the middle of the night) or difficulty tolerating PAP were additionally treated with medicines that suppress arousals/awakenings (trazodone, mirtazapine, doxepin). A total of 120 of 151 (79%) new patients were 70% PAP adherent over a continuous 30-day period, typically within the first 90 days of starting PAP, without sedating medicines. Nineteen of the remaining patients were treated with medicines that suppress arousals and awakenings, and 16 became adherent, resulting in 136 (90%) of 151 new patients achieving adherence. There were no differences in baseline sleep efficiency or arousal index, between adherent and nonadherent patients, as well as between patients who needed sedating medicines for PAP adherence and those who did not. Adding medicines that suppress arousals and awakenings for patients having trouble tolerating PAP, increases the number of patients who are PAP adherent. The need for such medicines seems to be related to the PAP side effect of increased awakenings rather than baseline impaired sleep.
机译：正气道压力（PAP）是阻塞性睡眠呼吸暂停（OSA）的优选治疗，但粘附性低。教育或正在进行的支持性干预可提高来自50％至70％范围的PAP抗粘附患者的数量。 PAP的常见副作用增加了觉醒。这种预期试验检查了PAP粘附和非抗震患者的基线多仪表衍生的睡眠效率和唤醒指数，并且在需要镇静药物以获得PAP粘附的患者与那些不需要这种药物的患者。在多瘤过程中滴定患有OSA的患者，或用自身侵蚀PAP治疗，接着是教育和支持性的干预措施。患有PAP相关觉得的患者（描述醒来并在半夜醒来的患者患者）或含有抑制唤醒器/觉醒的药物（Trazodone，Mirtazapine，Doxepin）的药物治疗耐受性耐受性耐受性。共有120名151名（79％）新患者在连续30天内依赖于70％PAP粘附，通常在开始PAP的前90天内，没有镇静药物。剩下的患者含有抑制唤醒和唤醒的药物治疗，16名依恋，导致136（90％）的151名新患者实现遵守。基线睡眠效率或唤醒指数没有差异，粘附和非闭合患者之间，以及需要镇静药物的患者的患者，以便庇护所属和那些没有的人。添加抑制唤醒和觉得患者耐受性PAP的患者的药物增加了患者的患者数量。对这种药物的需求似乎与增加觉醒的PAP副作用而不是基线睡眠。

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