• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Neuronal Dysexcitability May Be a Biomarker of Migraine: A Visual Evoked Potential Study
【24h】

Neuronal Dysexcitability May Be a Biomarker of Migraine: A Visual Evoked Potential Study

机译：神经元Dysexcitability可以是偏头痛的生物标志物：视觉诱发的潜在研究

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We report neuronal sensitization and impaired habituation in migraine using pattern reversal visual evoked potential (PRVEP) and correlate these with clinical characteristics of migraine. Sixty-five migraineurs and 30 healthy controls were included. A detailed clinical examination was done and migraine characteristics, including migraine trigger, photophobia, phonophobia, and allodynia were noted. Consecutive 5 blocks of PRVEP were recorded averaging 100 epochs at 3 Hz stimuli. The amplitude of N75 and P100 were measured. Amplitude of first block was considered for sensitization, and impaired habituation was considered if any subsequent block was not suppressed. Migraineurs had sensitization of P100 (14.01 ± 6.02 vs 11.60 ± 5.17 μV; P = .049), but not of N75 (42.22 ± 4.79 vs 11.08 ± 4.56 μV; P = .27) compared with the controls. Impaired habituation of N75 was more marked and persisted up to fourth block of VEP recoding. Impaired habituation of P100 was significant only in the third block. Baseline N75 and P100 amplitudes were higher in females, and N75 was also higher in those with longer duration of illness. These phenomena did not correlate with visual triggers. Sensitization and impaired habituation were marked during headache. Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. These phenomena may be useful for therapeutic monitoring.
机译：我们使用模式逆转视觉诱发电位（PRVEP）报告偏头痛中的神经元致敏和患者受损，并将这些患者与偏头痛的临床特征相关联。包括六十五次偏头痛和30个健康对照。已经注意到详细的临床检查，并注意到偏头痛特征，包括偏头痛触发，噬菌体，阴道症和异常性。连续5个PRVEP在3 Hz刺激时记录平均100个时期。测量N75和P100的幅度。第一个块的幅度被认为是敏化，如果没有抑制任何后续块，则考虑受损的习惯。偏头痛具有P100的敏化（14.01±6.02 vs 11.60±5.17μV; p = .049），但与对照相比，N75的N75（42.22±4.79 Vs11.08±4.56μV; p = .27）。 N75的习惯受损更加明显，并且持续到第四个VEP嵌入障碍。 P100的习惯受损仅在第三块中显着。基线N75和P100振幅较高，雌性较高，疾病持续时间较长，N75也更高。这些现象与视觉触发不相关。在头痛期间，敏感和受损的习惯被标记。基于PRVEP发现，可以得出结论，偏头痛具有P100的敏化，并且特别是在头痛期间的N75的习惯受损。这些现象可能对治疗监测有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号