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首页> 外文期刊>Clinical EEG and neuroscience: official journal of the EEG and Clinical Neuroscience Society (ENCS) >Neurofeedback-Based Enhancement of Single-Trial Auditory Evoked Potentials: Treatment of Auditory Verbal Hallucinations in Schizophrenia
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Neurofeedback-Based Enhancement of Single-Trial Auditory Evoked Potentials: Treatment of Auditory Verbal Hallucinations in Schizophrenia

机译：基于神经融合的单次试验诱发电位的增强：治疗精神分裂症中的听觉言语幻觉

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摘要

Auditory verbal hallucinations depend on a broad neurobiological network ranging from the auditory system to language as well as memory-related processes. As part of this, the auditory N100 event-related potential (ERP) component is attenuated in patients with schizophrenia, with stronger attenuation occurring during auditory verbal hallucinations. Changes in the N100 component assumingly reflect disturbed responsiveness of the auditory system toward external stimuli in schizophrenia. With this premise, we investigated the therapeutic utility of neurofeedback training to modulate the auditory-evoked N100 component in patients with schizophrenia and associated auditory verbal hallucinations. Ten patients completed electroencephalography neurofeedback training for modulation of N100 (treatment condition) or another unrelated component, P200 (control condition). On a behavioral level, only the control group showed a tendency for symptom improvement in the Positive and Negative Syndrome Scale total score in a pre-/postcomparison (t((4)) = 2.71, P = .054); however, no significant differences were found in specific hallucination related symptoms (t((7)) = -0.53, P = .62). There was no significant overall effect of neurofeedback training on ERP components in our paradigm; however, we were able to identify different learning patterns, and found a correlation between learning and improvement in auditory verbal hallucination symptoms across training sessions (r = 0.664, n = 9, P = .05). This effect results, with cautious interpretation due to the small sample size, primarily from the treatment group (r = 0.97, n = 4, P = .03). In particular, a within-session learning parameter showed utility for predicting symptom improvement with neurofeedback training. In conclusion, patients with schizophrenia and associated auditory verbal hallucinations who exhibit a learning pattern more characterized by within-session aptitude may benefit from electroencephalography neurofeedback. Furthermore, independent of the training group, a significant spatial pre-post difference was found in the event-related component P200 (P = .04).
机译：听觉言语幻觉取决于广泛的神经生物学网络，从听觉系统到语言以及与内存相关的过程。作为其中的一部分，听觉N100事件相关的电位（ERP）组分在精神分裂症患者中衰减，在听觉口头幻觉期间发生较强的衰减。 N100分量的变化假定地反映了精神分裂症中对听觉系统的干扰响应性。通过这个前提，我们调查了神经融合训练的治疗效用，以调节精神分裂症和相关听觉口头幻觉的患者的听觉诱发的N100组分。 10名患者完成了脑电图神经融合训练，用于调节N100（治疗条件）或另一种无关组分P200（控制条件）。在行为水平上，只有对照组才显示出症状改善症状的症状，阳性和阴性综合征尺度的总分数（T（4））= 2.71，p = .054）;然而，在特定的幻觉相关症状中没有发现显着差异（T（（7））= -0.53，p = .62）。神经融合背面对我们的范式中ERP组件的训练没有显着的整体效果;但是，我们能够识别不同的学习模式，发现训练会话的感觉语言幻觉症状的学习和改善之间的相关性（r = 0.664，n = 9，p = .05）。由于样品尺寸小，主要来自治疗组（r = 0.97，n = 4，p = .03），这种效果结果具有谨慎的诠释。特别是，在会话内学习参数显示了预测与神经融合训练的症状改善的效用。总之，具有精神分裂症和相关的听觉言语幻觉的患者，他们表现出在会话内能力内容的学习模式的表现，可以受益于脑电图神经融合。此外，独立于训练组，在事件相关的组件P200中发现了显着的空间预差异（p = .04）。

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