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首页> 外文期刊>Clinical neuropharmacology >Concentration-effect relationship of levodopa-benserazide dispersible formulation versus standard form in the treatment of complicated motor response fluctuations in Parkinson's disease.
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Concentration-effect relationship of levodopa-benserazide dispersible formulation versus standard form in the treatment of complicated motor response fluctuations in Parkinson's disease.

机译：左流血症分散配方与标准形式在帕金森病中复杂电机响应波动中的浓度效应关系。

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摘要

We compared the kinetic-dynamic profile of a postprandial dose of levodopa-benserazide dispersible formulation to that of the standard form in eight patients with parkinsonism presenting delayed or irregular patterns of after-meal levodopa dose effects. Patients were studied on two occasions, one week apart, according to an intra-subject randomized cross-over design. Thirty minutes after the consumption of a standard meal, patients received their usual levodopa-benserazide postprandial dose, on one occasion in the standard formulation and on the other one in the dispersible form. Blood venous samples for analysis of plasma levodopa concentrations were drawn at 15-minute intervals for the first 2 hours, then half-hourly until 5 hours after dosing. Motor response to the levodopa test dose was assessed by the finger tapping test at the same times as blood was sampled. The only statistically significant finding was a shorter time to peak plasma levodopa concentration with the levodopa-benserazide dispersible formulation compared with the standard form, whereas comparisons of levodopa pharmacodynamics showed little advantage of either formulation. Considering that liquid formulations of levodopa are less practical, we suggest reserving dispersible levodopa-benserazide tablets for selected patients and carefully monitoring drug dose motor response.
机译：将左旋多巴 - 丧料代的左旋多唑类化合物的动力学曲线与帕金纳病延迟或不规则模式的左右左旋多巴剂量效应的延迟或不规则模式进行比较至标准形式。根据主题内部随机交叉设计，将患者分两间进行两次，分开。在25分钟后，患者的消耗消耗，患者在标准制剂的一次性中接受了通常的左脂泮 - 丧料酰胺，一次性剂量，并在其他一个中的可分散形式。对于第2小时的前2小时以15分钟的间隔以15分钟的间隔绘制血静脉样品，然后将半小时为直至给药后5小时。随着对血液进行的同时，通过手指攻丝试验评估对左旋多巴试验剂量的电动机响应。与标准形式相比，唯一的统计学显着发现是脂肪醇左旋多巴浓度与左泊泮 - 囊植物可分散的制剂相比较短的时间，而左旋多巴药效学的比较表现出无论是制剂的少于优势。考虑到Levodopa的液体配方不太实用，我们建议为选定患者预留分散的左流鼠丧生，并仔细监测药物剂量电机响应。

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