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P372 Inference of intra and inter hippocampal directed causal relationships based on foramen ovale recordings

机译：基于Foramen Overale录音的P372 intra和海马型的跨海球型定向因果关系

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Objectives The traditional method for seizure onset zone determination is based on the temporal order in the appearance of pathological waveforms. However, this method assumes, that the well observable pathological waveforms are really the first signs of those processes, which play important role in the seizure generation. Our objective is to develop and apply new mathematical methods to identify the causal relations between brain areas during epileptic activity. Methods The Convergent Cross Mapping method of Sugihara was modified to reveal temporal dynamics of causal connections, and applied to current source density distribution data calculated from multichannel foramen ovale electrode recordings. Results The causality analysis revealed directed connections between the two hippocampi and specific changes in intra and inter-hippocampal connections comparing interictal and ictal periods: intrahippocampal connections get stronger and spread away spatially, while inter-hippocampal connections show more complex temporal development patterns during the seizures: the functional connectivity decreases during initial phase of the seizures in some cases, while increases during the full blown seizures. Onset of the tonic phases accompanied by temporal increase of the causal connections between the two hippocampi as well. Conclusions New mathematical analysis method, such as Convergent Cross Mapping raise the possibility of objective determination the causal relationships at the initiation of the seizure, without specific assumptions about the waveforms. Significance Causality analysis can support more precise identification of seizure onset zones, thus results in better surgical outcome. ]]>
机译：目的，传统的癫痫发作场测定方法基于病态波形外观中的时间顺序。然而，这种方法假设，井观察到的病理波形真的是那些过程的第一个迹象，这在癫痫发作中发挥着重要作用。我们的目标是开发和应用新的数学方法，以确定癫痫活动期间脑区域之间的因果关系。方法修改了Sugihara的收敛交叉映射方法，揭示了因果关系的时间动态，并应用于来自多通道孔卵形电极记录计算的电流源密度分布数据。结果因果区分析显示了两种海马和海洋动物间连接的特定变化的指导连接，比较了Interrictal和ICTAL期间：肠内捕集性连接在空间上变得更强烈并散布，而海洋跨度连接在癫痫发作期间显示出更复杂的时间发育模式。 ：在某些情况下，在癫痫发作的初始阶段，功能连接在次要阶段减少，而在完全吹癫痫发作期间增加。滋补阶段的发作伴随着两只海马之间的因果关系的时间增加。结论新的数学分析方法，如收敛交叉映射提高客观确定在癫痫发起时的因果关系的可能性，没有关于波形的具体假设。显着性因果区分析可以支持更精确的癫痫发作区域鉴定，从而导致更好的手术结果。 ]]>

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