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首页> 外文期刊>Clinical oral investigations >Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies
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Effect of non-surgical periodontal therapy on renal function in chronic kidney disease patients with periodontitis: a systematic review and meta-analysis of interventional studies

机译：非外科牙周治疗对牙周炎慢性肾病患者肾功能的影响：介入研究的系统审查与荟萃分析

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Objective This systematic review evaluated the impacts of non-surgical periodontal therapy (NSPT) in patients with chronic kidney disease (CKD) and periodontitis in order to explore causality and assess the potential benefits of co-management. Methods This systematic review and meta-analyses were conducted by searching MEDLINE, EMBASE, PubMed, Cochrane Library, and Open GREY. Interventional studies of adult patients suffering from CKD and periodontitis were investigated. Effect of NSPT on renal function was analyzed. Results A total of 109 participants from four case-series studies and 97 participants from one randomized controlled trial were included in this review. Sixty percent of the eligible studies (3/5) aimed at the effect of NSPT on nutritional status and systemic inflammation in dialysis patients. The other two studies concluded a beneficial impact of NSPT on estimated glomerular filtration rate (eGFR) in patients with CKD stages 2-4. Moreover, two meta-analyses were accomplished on eGFR and serum creatinine to evaluate the changes between baseline and 3-month follow-up. The pooled mean of eGFR was not significantly different pre- and post-NSPT using random and fixed-effect models. The change for creatinine was not significant using the random effect model but was significant when the fixed effect model was used (p < 0.001). Conclusions There is insufficient evidence to conclude the potential benefit of NSPT on renal function in CKD patients with periodontitis.
机译：目的该系统综述评估了非外科牙周治疗（NSPT）对慢性肾病（CKD）和牙周炎患者的影响，以探索因果关系并评估共同管理的潜在利益。方法通过搜索Medline，Embase，PubMed，Cochrane图书馆进行这种系统审查和荟萃分析，并开放灰色。研究了患有CKD和牙周炎的成年患者的介入研究。分析了NSPT对肾功能的影响。结果共有四个案例系列研究的109名参与者和来自一个随机对照审判的97名参与者均包含在本综述中。符合条件的研究（3/5）的六十百分之六十旨在NSPT对透析患者营养状况和全身炎症的影响。另外两项研究总结了NSPT对CKD阶段2-4患者估计肾小球过滤速率（EGFR）的有益影响。此外，在EGFR和血清肌酸酐上完成了两种荟萃分析，以评估基线和3个月随访之间的变化。使用随机和固定效果模型，EGFR的汇总平均值并不明显不同于和后期。使用随机效应模型的肌酐的变化并不重要，但在使用固定效果模型时显着（P <0.001）。结论没有足够的证据表明NSPT对CKD牙周炎患者肾功能的潜在益处。

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