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首页> 外文期刊>Comparative biochemistry and physiology, Part D. Genomics & proteomics >Genome-wide identification and transcriptome-based expression profiling of Wnt gene family in Ruditapes philippinarum
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Genome-wide identification and transcriptome-based expression profiling of Wnt gene family in Ruditapes philippinarum

机译：基因组鉴定和基于转录的基于转录组合的WNT基因家族在菲律宾动物中的表达分析

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摘要

The Wnt genes encode a set of conserved glycoproteins regulating early development, cell proliferation and differentiation, and tissue regeneration in metazoans. In some mollusks, the knowledge of Wnt gene family has been limited because of the short of the genomic and transcriptomic resources. Ruditapes philippinarum is an economically important bivalve with a variety of shell coloration patterns and ability to regenerate its siphon. To gain a greater understanding of the evolutionary dynamics of Wnt gene family, we carried out a genome-wide identification and phylogenetic analysis of Wnt gene family in R. philippinarum and other four mollusks. A total of 12 Wnt genes were identified in the genome of R. philippinarum, and the dynamic patterns of gene conservation, loss and duplication of Wnt genes were analyzed in mollusks and model organisms. Furthermore, the transcriptome analyses demonstrated the expression profiles of the Wnt genes at different developmental stage, in adult tissues, during siphon regeneration, in four different shell color strains, and at uncolored and colored developmental stages in two different shell color strains. These findings suggest that the expansion of Wnt genes may play vital roles in the larval development, the formation of shell color pattern and siphon regeneration in R. philippinarum. This study provides a valuable insight into Wnt function and evolution in mollusks.
机译：WNT基因编码一套保守的糖蛋白调节早期发育，细胞增殖和分化，以及美观甲烷中的组织再生。在一些软体动物中，由于基因组和转录组资源的缺点，WNT基因家族的知识受到限制。 Ruditapes Philippinarum是一种经济上重要的双壳，具有各种壳着色模式和再生虹吸管的能力。为了更加了解WNT基因家族的进化动态，我们对R.菲律宾和其他四种软体动物进行了WNT基因家族的基因组鉴定和系统发育分析。在R.菲律宾的基因组中鉴定了总共12种WNT基因，在软体动物和模型生物中分析了基因保护，丧失和重复基因的动态模式。此外，转录组分析证明了在虹吸式再生期间在虹吸剂再生期间的不同发育阶段的WNT基因的表达谱，在四种不同的壳颜色菌株中，并且在两种不同的壳颜色菌株中的不同和着色的发育阶段。这些发现表明，WNT基因的扩张可能在幼虫发育中发挥重要作用，在R.菲律宾壳颜色模式和虹吸式再生中形成壳体颜色模式。本研究提供了对软体动物的WNT函数和演变的宝贵洞察力。

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