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首页> 外文期刊>Comparative biochemistry and physiology. Toxicology & pharmacology: CBP >Exposure to a Brazilian pulp mill effluent impacts the testis and liver in the zebrafish
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Exposure to a Brazilian pulp mill effluent impacts the testis and liver in the zebrafish

机译：暴露于巴西纸浆磨坊的流出物影响斑马鱼中的睾丸和肝脏

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摘要

While many studies have shown that pulp mill effluents can affect ovarian physiology in fish, far fewer studies have considered the effects in males. We conducted a lab study to examine the effects of effluent from a Brazilian pulp and paper mill on hepatic and testicular morphology and various aspects of testicular physiology in the zebrafish Danio rerio. Males were exposed to lab water (control) or 4% effluent for 14 days. Effluent exposure did not affect testis size as measured by the gonadosomatic index, but contributed to morphological changes in the seminiferous tubules. The number of cysts with histopathological changes was elevated in effluent-exposed fish and the number of cysts containing spermatids was significantly reduced. The testis of effluent exposed fish had reduced levels of lactate, elevated lactate dehydrogenase activity, increased levels of reactive oxygen species and reduced levels of phosphorylated P38 mitogen-activated protein kinase (pP38 MAPK). Separate studies showed that the addition of lactate to testicular tissue incubated in vitro increased the activation of P38 MAPK. Effluent exposure also increased vacuolization, necrosis, apoptosis, hyperemia, and fat infiltration of the hepatocytes. Collectively, we provide evidence of short term effects of pulp mill effluent on testicular and hepatic physiology and biochemistry in the zebrafish.
机译：虽然许多研究表明，纸浆磨流水可能会影响鱼类中的卵巢生理学，但研究较少的研究考虑了雄性的影响。我们进行了一项实验室研究，以研究Zebrafish Danio Rerio在肝脏和验证形态和睾丸生理学中患有巴西纸浆和造纸厂的影响。将雄性暴露于实验室水（对照）或4％流出物14天。流出暴露的暴露不会影响通过促性腺指数测量的睾丸尺寸，但是有助于半成管中的形态变化。污水暴露的鱼类升高了组织病理学变化的囊肿的数量，含有精子的囊肿的数量显着降低。流出物暴露鱼的睾丸含有较低的乳酸水平，升高的乳酸脱氢酶活性，反应性氧物质的水平增加，以及降低的磷酸化P38丝裂剂活化蛋白激酶（PP38 MAPK）。单独的研究表明，在体外加入乳酸乳酸乳酸盐增加了P38 MAPK的活化。污水暴露也增加了肝细胞的真空化，坏死，凋亡，充血和脂肪浸润。集体，我们提供纸浆磨坊流出物在斑马鱼中睾丸和肝脏生理学和生物化学的短期影响的证据。

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