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首页> 外文期刊>Comparative Medicine >PKM2 in Canine Mammary Tumors: Parallels to Human Breast Cancer
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PKM2 in Canine Mammary Tumors: Parallels to Human Breast Cancer

机译：PKM2在犬乳腺肿瘤中：对人乳腺癌的相似之处

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摘要

PKM2 is a pyruvate kinase isoform that is the final and rate-limiting step in aerobic glycolysis in tumor cells. Increased expression of PKM2 has been detected in human cancers. The present study examined the expression of PKM2 in canine mammary tumors and assessed its prognostic significance.Paraffin sections of 5 adenomas, 67 carcinomas, and 5 samples of nonneoplastic hyperplasia from 77 dogs, aged 8 to 18 y, were evaluated. Significantly higher levels of PKM2 were detected among the carcinomas compared with all other tissues examined. The level of PKM2 expression in carcinomatissue correlated positively with the tumor grade. These findings suggest that PKM2 may have a similar role in canine mammary tumors to its role in human breast cancer. As such, canine mammary tumors may be useful models for studies focused on the progression of human neoplastic disease.
机译：PKM2是一种丙酮酸激酶同种型，是肿瘤细胞中的有氧糖溶解中的最终和速率限制步骤。 在人类癌症中检测到pKM2的表达增加。 本研究检测了PKM2在犬乳腺肿瘤中的表达，评估了其5岁腺瘤，67个癌的甲脒部分，77只狗的非孕术增生和5岁的非孕型异常增生。 与所检查的所有其他组织相比，在癌中检测到显着较高的PKM2水平。 Carcinatisueue中PKM2表达的水平与肿瘤等级正相关。 这些发现表明，PKM2可能在犬乳腺癌中具有与其在人乳腺癌中的作用类似的作用。 因此，犬乳腺肿瘤可能是研究的有用模型，其专注于人肿瘤疾病的进展。

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  • 来源
    《Comparative Medicine》 |2020年第4期|共6页
  • 作者

    Lee Hyo-Ju; Han Hyo-Jeong; Lee Ji-Young; Son Woo-Chan;

  • 作者单位

    Department of Pathology University of Ulsan College of Medicine Asan Medical Center;

    Department of Pathology University of Ulsan College of Medicine Asan Medical Center;

    Department of Pathology University of Ulsan College of Medicine Asan Medical Center;

    Department of Pathology University of Ulsan College of Medicine Asan Medical Center;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
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