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首页> 外文期刊>Comparative Medicine >Evaluation of Peripheral Blood Markers as Early Endpoint Criteria in Guinea Pigs (Cavia porcellus) when Testing Tuberculosis Vaccine Candidates
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Evaluation of Peripheral Blood Markers as Early Endpoint Criteria in Guinea Pigs (Cavia porcellus) when Testing Tuberculosis Vaccine Candidates

机译：在测试结核病疫苗候选时，将外周血标记作为早期终点标准的评估豚鼠（CAVIA PORCELLUS）

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The guinea pig model of tuberculosis is used extensively to assess the efficacy of novel tuberculosis vaccines. There are established parameters to determine vaccine efficacy in this model, but the science community currently lacks established biomarkers for early detection and monitoring of experimental disease in guinea pigs. To define a set of biomarkers that could be used as benchmarks for disease progression and early endpoint criteria, we assessed serum biochemical and hematology parameters in 2 groups of guinea pigs-one vaccinated with the attenuated Mycobacterium bovis vaccine strain (BCG) and one sham-vaccinated with saline-and then experimentally infected with a virulent strain of Mycobacterium tuberculosis. After infection, WBC showed the strongest differences between saline-inoculated and vaccinated animals, with more subtle changes in other serum biochemical parameters, including ALT and ALP. Therefore, this study provides a starting point for evaluating the utility of blood values as possible early endpoint criteria in the guinea pig model of tuberculosis.
机译：结核病的豚鼠模型广泛用于评估新型结核病疫苗的疗效。确定参数来确定该模型中的疫苗疗效，但科学界目前缺乏已建立的生物标志物，用于早期检测和监测豚鼠实验疾病的生物标志物。为了定义一组可用作疾病进展和早期终点标准的基准的生物标志物，我们评估了2组豚鼠中的血清生物化学和血液学参数 - 与减毒的分枝杆菌疫苗菌株（BCG）和一个假的疫苗接种用盐水接种 - 然后通过实验感染了一种毒性的结核菌毒菌素。感染后，WBC在盐水接种和疫苗的动物之间表现出具有最强的差异，其它血清生物化学参数的更细微变化，包括ALT和ALP。因此，该研究提供了在结核病豚鼠模型中尽可能早期终点标准评估血值的效用的起点。

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