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首页> 外文期刊>Comparative Medicine >Diagnosis, Surveillance and Management of Streptococcus equi subspecies zooepidemicus Infections in Chinchillas (Chinchilla lanigera)
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Diagnosis, Surveillance and Management of Streptococcus equi subspecies zooepidemicus Infections in Chinchillas (Chinchilla lanigera)

机译：Chinchillas（Chinchilla Lanigera）Zoopidemicus感染的诊断，监测和管理Zoopidemicus感染

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During a 6-mo period, two 5-6 mo old female chinchillas (Chinchilla lanigera) were examined at the University of Colorado Anschutz Medical Campus after the discovery of firm, nonmobile masses in the left ventral cervical and left axillary region. Other than these findings andmild weight loss, both chinchillas' physical exams were normal. Bloodwork revealed an inflammatory leukogram characterized by leukocytosis, toxic neutrophils, lymphopenia, and monocytosis with mild, nonregenerative anemia. At necropsy, both masses were identified as abscesses. Streptococcusequi, subspecies zooepidemicus (S. zooepidemicus) was isolated in pure culture. Histology of the lungs, liver, spleen, and kidneys showed a marked increase in the numbers of both polymorphonuclear leukocytes and lymphocytes. Both animals were deemed unsuitable for researchand were euthanized under isoflurane anesthesia by an intracardiac injection of pentobarbital sodium solution. S. zooepidemicus is an opportunistic, commensal organism found in the upper respiratory tract of horses. This organism has been documented to cause disease in other speciesand is zoonotic. Infections in humans have been reported, resulting in glomerulonephritis, endocarditis, septic arthritis, osteomyelitis, meningitis, and death. To aid in diagnosis and prospective surveillance of this bacteria, oral and nasal swabs were collected from the remaining cohortof chinchillas, and a qPCR screening assay was implemented. Within 12 mo, 4 of 41 additional females tested positive by culture or qPCR, resulting in a disease prevalence of 14% (6 of 43). However, only 2 of the additional 4 S. zooepidemicus positive animals developed clinical signs.The potential for the spread of infection, zoonosis, and adverse effects on research demonstrate that surveillance for S. zooepidemicus should be considered in a biomedical research environment.
机译：在左侧腹部宫颈和左侧腋窝的非致残群体发现，在科罗拉多州安斯库茨医学校园大学审查了两名5-6莫老雌性Chinchillas（Chinchilla Lanigera）。除了这些发现和体重减轻之外，汉奇拉斯的体检是正常的。血液揭示了一种炎症性白细胞，其特征是白细胞增多症，有毒中性粒细胞，淋巴细胞酵母和单胞赘，具有轻度，非再生性贫血。在尸检时，两种群众被识别为脓肿。 Streptococcusqui，亚种Zooepidemicus（Zooepidemicus）在纯​​文化中孤立。肺，肝，脾和肾脏的组织学表现出多核白细胞和淋巴细胞的数量显着增加。两只动物被认为不适合通过肝癌钠溶液的肠道内注射异氟醚麻醉被安乐死。 S. Zooepidemicus是一种机会主义，在马匹上呼吸道中发现。这种有机体已被记录在其他物种中引起疾病​​和是一种人群。报告了人类的感染，导致肾小球肾炎，心内膜炎，脓肠炎，骨髓炎，脑膜炎和死亡。为了帮助诊断和前瞻性监测该细菌，从剩余的Cohortof Chinchillas收集口腔和鼻拭子，并实施了QPCR筛查检测。在12月内，41个额外的女性中的4个培养或QPCR测试阳性，导致疾病患病率为14％（63分）。然而，另外的4次Zooepidemicus阳性动物中只有2种临床症状。感染蔓延，人畜共患病和对研究的不利影响的可能性表明，在生物医学研究环境中应考虑对Zoopidemus的监测。

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