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Identifying and Implementing Endpoints for Geriatric Mice

机译：识别和实施GeriTric小鼠的终点

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摘要

The types of changes in physical appearance and behavior that occur in elderly people similarly develop in elderly animals. Signs and symptoms that might cause concern in younger people or mice may be normal in their elderly but generally healthy counterparts. Although numerous scoring methods have been developed to assess rodent health, these systems were often designed for young adults used in specific types of research, such as cancer or neurologic studies, and therefore may be suboptimal for assessing aging rodents. Approaches known as frailty assessments provide a global evaluation of the health of aged mice, rats, and people, and mouse frailty scores correlate well with the likelihood of death. Complementing frailty assessment, prediction of imminent death in aged mice can often be accomplished by focusing on 2 objective parameters-body weight and temperature. Before they die, many (but not all) mice develop marked reductions in body weight and temperature, thus providing signs that close monitoring, intervention, or preemptive euthanasia may be necessary. Timely preemptive euthanasia allows antemortem collection of data and samples that would be lost if spontaneous death occurred; preemptive euthanasia also limits terminal suffering. These approaches to monitoring declining health and predicting death in elderly research mice can aid in establishing and implementing timely interventions that both benefit the research and reduce antemortem suffering.
机译：老年人在老年人中发生的身体外观和行为的变化类型。可能导致年轻人或小鼠造成疑虑的迹象和症状可能是他们的老年人，但通常是健康的同行中的正常情况。尽管已经开发了许多评分方法来评估啮齿动物的健康，但这些系统通常为用于特定类型的研究的年轻成年人，例如癌症或神经系统研究，因此可能是评估老化啮齿动物的次优。被称为脆弱评估的方法提供了对老年小鼠，大鼠和人民的健康的全球评估，小鼠脆弱的分数与死亡的可能性很好地关联。补充脆弱的评估，通常可以通过专注于2个目标参数体重和温度来实现迫在眉睫的小鼠迫在眉睫的死亡。在他们死之前，许多（但不是全部）小鼠在体重和温度下显着降低，从而提供了密切监测，干预或先发制人的安乐死的迹象。及时先发制人的安乐死，如果发生自发死亡，可以丢失的数据和样品的抗emortem收集;先发制人的安乐死也限制了终端痛苦。这些方法监测健康衰退和预测老年研究小鼠的死亡可以有助于建立和实施及时干预，这些干预措施都有利于研究和减少抗恶化痛苦。

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