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首页> 外文期刊>Comparative Medicine >Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice
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Betamethasone Treatment for Atopic Dermatitis in Gut Microbiota Transplanted Mice

机译：肠道微生物膜移植小鼠特应性皮炎的雌滴虫治疗

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摘要

Gut microbiota composition correlates strongly with essential disease parameters in the oxazolone-induced mouse model for atopic dermatitis. The phenotype of this model can be transferred to germ-free mice with a gut microbiota transplant to achieve high and low responding mice. Therefore, the production of high responding mice through gut microbiota transplantation may be seen as a tool to reduce group sizes or increase power in intervention studies by increasing effect size. We sought to determine whether high responding mice respond to a common treatment in the same way as low responding mice. We hypothesized that while high responding mice would exhibit a higher clinical score than low responding mice before treatment, the clinical parameters would be similar in both groups after betamethasone treatment. Dermatitis was induced with oxazolone in barrier bred Swiss Webster mice, and a high responding and a low responding donor was selected based upon clinical and pathologic scores, as confirmed by monitoring a range of ear tissue cytokines. Feces from these donors were transplanted to pregnant germ-free Swiss Webster dams, and subsequently to their offspring. Although the overall effect of betamethasone on the clinical dermatitis score and ear thickness was rather small, the high responding recipients had significantly higher clinical dermatitis score and ear thickness than the low responding recipients before treatment, and these differences vanished after betamethasone treatment. We conclude that high responding recipients can be treated to a clinical level comparable with the low responding recipients.
机译：肠道微生物群组合物在恶唑龙诱导的小鼠模型中强烈地相关疾病参数，用于特应性皮炎。该模型的表型可以转移到具有肠道微生物移植的无菌小鼠，以实现高低应答的小鼠。因此，通过肠道微生物会移植的高响应小鼠的产生可以被视为通过增加效果大小来减少群体尺寸或增加干预研究中功率的工具。我们试图以与低响应小鼠相同的方式判断高响应小鼠是否对常见的治疗相同。我们假设虽然在治疗前表现出高响应小鼠的高响应小鼠的临床评分，但临床参数在均多次滴体处理后在两组中都存在相似。用恶唑酮在屏障中诱导皮炎培育瑞士韦伯斯特小鼠，并且基于临床和病理评分选择高响应和低响应供体，如通过监测一系列耳组织细胞因子的确认。这些捐赠者的粪便被移植到怀孕的无菌瑞士韦伯斯坝上，随后在其后代。虽然脂肪酸滴虫对临床皮炎得分和耳朵厚度的总体影响相当小，但高响应受者的临床皮炎得分和耳朵厚度明显高于治疗前的低响应接受者，并且这些差异在烘焙后的处理后消失。我们得出结论，高响应接受者可以治疗与低响应接受者相当的临床水平。

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  • 来源
    《Comparative Medicine》 |2020年第1期|共10页
  • 作者

    Debes Karina P.; Evdina Nathalie A.; Laigaard Ann; Larsen Julie M.; Zachariassen Line F.; Hansen Camilla H. F.; Hansen Axel K.;

  • 作者单位

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Vet &

    Anim Sci Sect Expt Anim Models Frederiksberg C Denmark;

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  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
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