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An International Survey of Approaches to Chair Restraint of Nonhuman Primates

机译：非人兴灵征克制措施途径的国际调查

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Specifically designed restraint chairs are the preferred method of restraint for research studies that require NHP to sit in place for sustained periods of time. In light of increasing emphasis on refinement of restraint to improve animal wellbeing, it is important to have a better understanding of this potentially stressful procedure. Although chair restraint is used internationally, very little published information is available on this subject. We developed a survey to obtain an overview of equipment, procedures, and plans for improvement regarding chair restraint. We received 101 responses from people working in academic, government, contract research, and pharmaceutical laboratories within the Americas, Europe and Asia. Findings indicate that the majority of laboratories using restraint chairs work with macaque species. Restraint chairs are used for a wide range of procedures, including cognitive testing, recording neuronal activity, functional MRI, intravenous infusion, and blood sampling. Approximately 2/3 of laboratories use an enclosed 'box chair,' which the animal is trained to enter and then to extend its head through an opening on the top of the chair; the remaining one third of laboratories use an 'open chair' design, in which manual handling or the pole-and-collar system is used to transfer and secure the animal into the chair. Respondents reported that when selecting the type of chair to use, they considered comfort for the animal, ease of use, and the ability to adjust fit between animals of different sizes. Various training methods and timeframes are used to prepare macaques for restraint chair procedures. Several laboratories are incorporating greater use of positive reinforcement training. The community that uses these restraint procedures needs to work together to define best practice; our survey results can help in that effort.
机译：专门设计的克制椅是用于研究研究的首选方法，要求NHP坐在适当的时间内。鉴于提高限制改善动物健康的改进，重要的是要更好地了解这种潜在的压力程序。虽然在国际上使用了椅子克制，但在此主题上提供了很少的公布信息。我们制定了一项调查，以获取有关椅子克制的设备，程序和改进计划的概述。我们收到了在美洲，欧洲和亚洲的学术，政府，合同研究和制药实验室工作的101人回应。调查结果表明，大多数实验室使用克制椅子与猕三方物种一起使用。约束椅用于广泛的程序，包括认知测试，记录神经元活动，功能性MRI，静脉注射输注和血液取样。大约2/3的实验室使用封闭的“盒子”椅子，动物培训进入，然后将头部延伸穿过椅子顶部的开口;剩下的三分之一的实验室使用了“开放式椅子”设计，其中手动处理或极点系统用于将动物固定到椅子上。受访者报告说，在选择要使用的椅子类型时，他们考虑了动物，易用性以及调整不同尺寸的动物之间的能力。各种训练方法和时间帧用于准备克拉林椅手续的Macaques。若干实验室正在加大阳性加固训练的使用。使用这些克制程序的社区需要共同努力来定义最佳实践;我们的调查结果可以帮助这种努力。

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