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Longitudinal Anthropometric Assessment of Rhesus Macaque (Macaca mulatta) Model of Huntington Disease

机译：亨廷顿疾病岩藻猕猴（Macaca Mulatta）模型的纵向主义评估

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摘要

The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans. In children at risk for HD, body measurement growth abnormalities include a reduction in BMI, weight, height, and headcircumference. The transgenic HD NHP model was first reported in 2008, and progressive decline in cognitive behaviors and motor impairment have been reported. This study focuses on longitudinal body measurements in HD macaques from infancy through adulthood. The growth of HD macaques was assessedthrough head circumference, sagittal and transverse head, and crown-to-rump ('height') measurements and BMI. The animals were measured monthly from 0 to 72 mo of age and every 3 mo from 72 mo of age onward. A mixed-effect model was used to assess subject-specific effects in our nonlinear serialdata. Compared with WT controls, HD macaques displayed different developmental trajectories characterized by increased BMI, head circumference, and sagittal head measurements beginning around 40 mo of age. The physiologic comparability between NHP and humans underscores the translational utilityof our HD macaques to evaluate growth and developmental patterns associated with HD.
机译：与亨廷顿疾病（HD）相关的神经变性导致电机和认知障碍的发病及其在人类增加的年龄增加。在HD风险的儿童中，身体测量生长异常包括BMI，重量，高度和头部流量的降低。 2008年首次报道了转基因HD NHP模型，报告了认知行为和汽车损害的逐步下降。这项研究侧重于来自Afuthood的HD Macaques中的纵向体测量。高清猕猴的生长是评估通电头圆周，矢状和横向头，以及冠状峰（'高度'）测量和BMI。每月测量的动物从0到72℃的每月测量，并且每3MO每3Mo到72莫。混合效应模型用于评估我们的非线性序列数据中的对象特异性效果。与WT控制相比，高清猕猴显示出不同的发育轨迹，其特征在于BMI，头圆周和矢状头测量增加，从年龄40莫左右开始。 NHP与人类之间的生理可比性强调了我们高清猕猴的翻译效用，以评估与HD相关的生长和发育模式。

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