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首页> 外文期刊>Comparative Medicine >Using the Oculocardiac Reflex to Characterize Autonomic Imbalance in a Naturally Occurring Canine Model of Valvular Insufficiency
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Using the Oculocardiac Reflex to Characterize Autonomic Imbalance in a Naturally Occurring Canine Model of Valvular Insufficiency

机译：使用oculocardarciac反射来表征在天然存在的瓣膜功能不全的犬类模型中的自主性失衡

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摘要

Congestive heart failure (CHF) is characterized by reduced heart rate variability. Although various methods to achieve parasympathetic withdrawal and sympathetic activation have been documented, stimulation of the vagal nerve (that is, vagal maneuvers) has not often been used to assessthe autonomic impairment associated with disease progression in veterinary species. In this study, we investigated cardiac autonomic control in a naturally occurring canine model of mitral insufficiency by means of individual responses to oculocardiac reflex. Indices of heart rate variabilitywere calculated from 5-min ECG tracings obtained before and after ocular compression. After compression, significant increases in the standard deviation of RR intervals, root mean square of the successive differences in RR intervals, and vasovagal tonus index were documented in healthy controlanimals. In addition, these indices were increased in asymptomatic dogs with remodeled hearts, but no variation occurred in symptomatic animals. Although only the percentage change in vasovagal tonus index differed significantly between controls and diseased dogs, all other parameters showeda tendency to behave the opposite way in the symptomatic group as in the control and asymptomatic groups. Our results document CHF-dependent autonomic dysfunction in a canine model of valve insufficiency.
机译：充血性心力衰竭（CHF）的特征在于心率变化降低。虽然已经记录了各种方法来实现副交感神经戒断和交感神经激活，但刺激迷走神经（即迷走式动作）并未用于评估兽医物种中与疾病进展相关的自主主义损伤。在这项研究中，我们通过对血肿反射的个体反应来研究在二尖瓣内部不足的天然犬模型中的心脏自主控制。从眼压缩前后获得的5分钟的心电图曲线计算的心率变化的指标。在压缩之后，RR间隔的标准偏差显着增加，RR间隔连续差异的根均线和血管无血管舌头指数被记录在健康的Contractanimals中。此外，这些索引在无症状的狗中增加了具有重新模拟的心脏，但在症状动物中没有变异。虽然对照组和患病犬只有血管加湿吨素指数的百分比变化显着不同，但所有其他参数显示出在对照组中表现出对照和无症状的相反的方式。我们的结果在阀空气功能不全的犬模型中依赖于CHF依赖性自主功能障碍。

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