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首页> 外文期刊>Comparative Medicine >Defining and Managing Pain in Stroke and Traumatic Brain Injury Research
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Defining and Managing Pain in Stroke and Traumatic Brain Injury Research

机译：在中风和创伤性脑损伤研究中定义和管理疼痛

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摘要

Neurologic conditions such as stroke and traumatic brain injury are challenging conditions to study in humans. Animal models are necessary to uncover disease processes and develop novel therapies. When attempting to model these or other neurologic diseases, the accompanying anesthesia and analgesia create variables that are not part of the onset of the clinical disease in the human population but are critical components of the postinjury care both in humans and animals. To maximize model validity, researchers must consider whether the disease process or a novel therapy is being studied. Damage to the neurons of the brain or the spinal cord is not painful at the neural tissue itself, but alterations to nociceptive signaling along the pain pathway can induce chronic pain. In addition, trauma or surgery leading to the event is associated with damage to peripheral tissue. Inflammation is inextricably associated with tissue injury. Inflammation is known to evoke nociception in the periphery and drive long-term changes to neurons in the CNS. Analgesics and anesthetics alter these responses yet are required as part of humane animal care. Careful planning for effective drug administration consistent with the standard of care for humans and equivalent animal care is required.
机译：中风和创伤性脑损伤的神经系统条件是对人类研究的挑战性的条件。动物模型是揭开疾病过程和开发新的疗法所必需的。当试图模拟这些或其他神经系统疾病时，随附的麻醉和镇痛创造不包括人口临床疾病发作的一部分的变量，而是在人类和动物中关注的Postinjury护理的关键组成部分。为了最大限度地提高模型有效性，研究人员必须考虑是否正在研究疾病过程或新疗法。对大脑的神经元或脊髓的损伤在神经组织本身上并不痛苦，而是沿着疼痛途径的伤害性信号传导的改变可以诱导慢性疼痛。此外，导致事件的创伤或手术与对外周组织的损伤有关。炎症与组织损伤密不可不可。已知炎症以唤起周边的伤害，并在CNS中促进对神经元的长期变化。镇痛药和麻醉剂改变了这些响应，尚未作为人文动物护理的一部分。需要仔细规划与人类和同等动物护理的护理标准一致的有效药物管理局规划。

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