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首页> 外文期刊>Comparative Medicine >Lack of Effect of Murine Norovirus Infection on the CD4(+)CD45RB(high) T-cell Adoptive Transfer Mouse Model of Inflammatory Bowel Disease
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Lack of Effect of Murine Norovirus Infection on the CD4(+)CD45RB(high) T-cell Adoptive Transfer Mouse Model of Inflammatory Bowel Disease

机译：小鼠诺罗病毒感染对CD4（+）CD45RB（高）T细胞养致炎性肠病疾病的缺乏影响

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Murine norovirus (MNV) infection is highly prevalent in laboratory mice. Although MNV infection does not typically induce clinical disease in most laboratory mice, infection may nonetheless affect mouse models of disease by altering immune responses. We previously reported that MNV altered the bacterial-induced mouse model of inflammatory bowel disease (IBD) using Helicobacter-infected Mdr1a(-/-) mice. Therefore, we hypothesized that MNV infection would exacerbate another mouse model of IBD, the T-cell adoptive transfer (AT) model. In this model, Helicobacter infection is used to accelerate the progression of IBD induced by AT of naive CD4(+)CD45RB(high) T cells into B6.129S7-Rag1(tm1Mom)/J (Rag1(-/-)) mice. We evaluated the effects of MNV infection in both Helicobacter-accelerated as well as Helicobacter-free AT models. In our studies, Helicobacter-infected Rag1(-/-) mice that received CD4(+)CD45RB(high) T cells through AT rapidly developed weight loss and typhlocolitis; MNV infection had no effect on disease severity or rate of progression. In the absence of Helicobacter infection, progression of IBD caused by AT of CD4(+)CD45RB(high) T cells was slower and typhlocolitis was less severe; this inflammation likewise was unaltered by MNV infection. These results indicate that MNV infection does not alter IBD progression and severity in the CD4(+)CD45RB(high) T-cell AT model in Rag1(-/-) mice.
机译：鼠诺维病毒（MNV）感染在实验室小鼠中普遍普遍。虽然MNV感染通常在大多数实验室小鼠中通常不会诱导临床疾病，但是感染可能仍可能通过改变免疫应答来影响疾病的小鼠模型。我们以前报道，MNV使用幽门术感染的MDR1A（ - / - ）小鼠改变了细菌诱导的炎症性肠病（IBD）的小鼠模型。因此，我们假设MNV感染会加剧IBD的另一种小鼠模型，T细胞养护转移（AT）模型。在该模型中，幽门杆菌感染用于加速天然CD4（+）CD45RB（高）T细胞AT诱导的IBD进展到B6.129S7-RAG1（TM1MOM）/ J（RAG1（ - / - ））小鼠中。我们评估了MNV感染在螺杆术中的影响以及在模型中无螺旋菌的影响。在我们的研究中，感染的RAG1（ - / - ）小鼠通过在迅速发展的体重减轻和育龄菌炎中获得CD4（+）CD45RB（高）T细胞; MNV感染对疾病严重程度或进展速率没有影响。在没有升降杆菌感染的情况下，由CD4（+）CD45RB（高）T细胞AT引起的IBD的进展较慢，剧痛炎严重严重;这种炎症同样是通过MNV感染的爆发。这些结果表明，MNV感染在RAG1（/ - / - ）小鼠模型中的CD4（+）CD45RB（高）T细胞中不会改变IBD进展和严重程度。

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