• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Clinical Management of Pain in Rodents
【24h】

Clinical Management of Pain in Rodents

机译：啮齿动物疼痛的临床管理

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of effective regimens for mitigating pain remain underutilized in research rodents despite the general acceptance of both the ethical imperative and regulatory requirements intended to maximize animal welfare. Factors contributing to this gap between the need for and the actual use of analgesia include lack of sufficient evidence-based data on effective regimens, under-dosing due to labor required to dose analgesics at appropriate intervals, concerns that the use of analgesics may impact study outcomes, and beliefs that rodents recover quickly from invasive procedures and as such do not need analgesics. Fundamentally, any discussion of clinical management of pain in rodents must recognize that nociceptive pathways and pain signaling mechanisms are highly conserved across mammalian species, and that central processing of pain is largely equivalent in rodents and other larger research species such as dogs, cats, or primates. Other obstacles to effective pain management in rodents have been the lack of objective, science-driven data on pain assessment, and the availability of appropriate pharmacological tools for pain mitigation. To address this deficit, we have reviewed and summarized the available publications on pain management in rats, mice and guinea pigs. Different drug classes and specific pharmacokinetic profiles, recommended dosages, and routes of administration are discussed, and updated recommendations are provided. Nonpharmacologic tools for increasing the comfort and wellbeing of research animals are also discussed. The potential adverse effects of analgesics are also reviewed. While gaps still exist in our understanding of clinical pain management in rodents, effective pharmacologic and nonpharmacologic strategies are available that can and should be used to provide analgesia while minimizing adverse effects. The key to effective clinical management of pain is thoughtful planning that incorporates study needs and veterinary guidance, knowledge of the pharmacokinetics and mechanisms of action of drugs being considered, careful attention to individual differences, and establishing an institutional culture that commits to pain management for all species as a central component of animal welfare.
机译：尽管普遍接受旨在最大化动物福利的伦理的迫切和监管要求，但在研究啮齿动物中，使用有效方案仍然在研究啮齿动物中仍然未充分利用。有助于这种差距与实际使用镇痛之间的差距包括缺乏有关有效方案的充分证据数据，由于在适当的间隔内剂量镇痛药所需的劳动所需的劳动力，镇痛药可能会影响研究结果，以及啮齿动物从侵入性程序中迅速恢复的结果，因此不需要镇痛药。从根本上讲，啮齿动物疼痛临床管理的任何讨论都必须认识到患有哺乳动物物种的伤害途径和疼痛信号传导机制在哺乳动物种类中受到高度保守，并且疼痛的中央加工在很大程度上在啮齿动物和其他较大的研究种类等狗，猫或其他较大的研究种类上灵长类动物。其他障碍在啮齿动物中有效疼痛管理的障碍一直是缺乏客观的科学驱动的疼痛评估数据，以及适当的药理学工具用于缓解缓解。为了解决这一赤字，我们已经审查并概述了大鼠，小鼠和豚鼠疼痛管理的可用出版物。讨论了不同的药物类别和特定的药代动力学曲线，推荐剂量和行政途径，并提供了更新的建议。还讨论了增加研究动物舒适和福祉的非武装工具。还审查了镇痛药的潜在不利影响。虽然在我们对啮齿动物的临床疼痛管理中仍然存在差距仍然存在，但可用的有效药理学和非武装策略可以并且应该用于提供镇痛，同时最小化不良反应。有效的临床管理的关键是贯穿研究需求和兽医指导，了解药代动力学和毒品的作用机制，仔细注意个人差异，并建立了对所有人致命管理的制度文化物种作为动物福利的中央部件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号