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首页> 外文期刊>Comparative Medicine >Pathologic Lesions of the Budgett Frog (Lepidobatrachus laevis), an Emerging Laboratory Animal Model
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Pathologic Lesions of the Budgett Frog (Lepidobatrachus laevis), an Emerging Laboratory Animal Model

机译：Budgett Frog（Lepidobatrachus Laevis）的病理病变，新兴的实验室动物模型

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Lepidobatrachus laevis, commonly called the Budgett frog, is a member of the horned frog family (Ceratophryidae), which has become increasingly popular among amphibian hobbyists. L. laevis is also used in biologic research on embryonic development, providing a novel modelspecies for the study of organogenesis, regeneration, evolution, and biologic scaling. However, little scientific literature details disease processes or histologic lesions in this species. Our objective was to describe spontaneous pathologic lesions in L. laevis to identify diseasephenotypes. We performed a retrospective analysis of 14 captive L. laevis frogs (wild-caught and captive-bred), necropsied at the NC State University College of Veterinary Medicine between 2008 and 2018. The majority of frogs exhibited renal changes, including varying combinations oftubular epithelial binucleation, karyomegaly, and cytoplasmic vacuolation; polycystic kidney disease; and renal carcinoma. Many of the renal changes are reminiscent of a condition described in Japanese (Bufo japonicus) and Chinese (Bufo raddei) toad hybrids that progresses fromtubular epithelial atypia and tubular dilation to polycystic kidney disease to renal carcinoma. A second common finding was variably sized, randomly distributed bile duct clusters (biliary proliferation). Other noteworthy findings included regional or generalized edema, intestinal adenocarcinoma,aspiration pneumonia, and parasitism. This retrospective analysis is the first description of histologic lesions identified in captive L. laevis populations, providing new insight into spontaneous disease processes occurring in this species for use in disease diagnosis and clinicalmanagement.
机译：Lepidobatrachus Laevis，通常称为Budgett Frog，是有角青蛙家族（Ceratophryidae）的成员，这在两栖业余爱好者中越来越受欢迎。 L. Laevis也用于胚胎发育的生物学研究，为有机组织，再生，进化和生物缩放提供了一种新型模特类。然而，小型科学文献细节细节本物种中的疾病过程或组织学病变。我们的目标是描述L. Laevis的自发病理病变，以识别疾病直型。我们在2008年至2018年间NC州立大学兽医学院进行了对14个俘虏L. Laevis Frogs（野生捕获和俘虏）的回顾性分析。大多数青蛙都表现出肾变化，包括调情上皮的不同组合Binucleation，Karyomegaly和细胞质真空;多囊肾;和肾癌。许多肾变化是让日语（Bufo Japonicus）和中医（Bufo Raddei）蟾蜍杂种中描述的病症，以便从直率上皮原型和管状扩张到多囊肾疾病到肾癌的杂种。第二种常见发现是可变的大小，随机分布的胆管簇（胆道增殖）。其他值得注意的发现包括区域或广义水肿，肠道腺癌，吸入性肺炎和寄生疫苗。该回顾性分析是在植入L. Laevis群中鉴定的组织学病变的第一次描述，提供了新的疾病，这些物种中发生的自发性疾病过程用于疾病诊断和临床管理。

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