• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Colloids and Surfaces, B. Biointerfaces >Pharmaceutical excipient salts effect on micellization and drug solubilization of PEO-PPO-ph-PPO-PEO block copolymer
【24h】

Pharmaceutical excipient salts effect on micellization and drug solubilization of PEO-PPO-ph-PPO-PEO block copolymer

机译：药物赋形剂盐对PPO-PH-PPO-PPO-PEO嵌段共聚物胶束化和药物溶解的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydrophobic modification PEO-PPO copolymer BP123 was synthesized, with two aromatic rings in the centre linked to PEO-PPO blocks, and the identical PEO and PPO block numbers were possessed with commercial copolymer P123. The influence of three common pharmaceutical excipient salts sodium chloride (NaCl), sodium citrate (NaCA) and sodium benzoate (NaBZ) on self-assembly behaviors of BP123 and P123 was investigated via cloud point, surface tension, pyrene fluorescence and dynamic light scattering. Solubilization for hydrophobic drug simvastatin (SV) and in vitro drug release behavior were assessed accordingly. In the presence of NaCl or NaCA, cloud point and critical micellization concentration (CMC) decreased, micelles became more hydrophobic, micellar size and drug solubilization increased, drug release rate slowed, and the impact of NaCA was more significant than NaCl. Oppositely, cloud point and CMC increased with the addition of NaBZ. NaBZ could participate in the formation of micelles by hydrophobic aromatic ring, which greatly raised solubilization of SV. Moreover, a different performance occurred when NaBZ was added to BP123 or P123, due to the hydrophobic benzene rings in BP123, which prominently enhanced the interaction with hydrophobic drug, leading to obvious delay of drug release for BP123. This work is conducive to turning copolymer property in diverse pharmaceutical applications and in drug delivery systems as drug carriers.
机译：合成疏水性修饰PEO-PPO共聚物BP123，与PEO-PPO嵌段连接的中心有两个芳环，并且具有商业共聚物P123具有相同的PEO和PPO嵌段数。通过浊点，表面张力，芘荧光和动态光散射研究了三种常见的药物赋形剂氯化钠（NaCl），柠檬酸钠（NaC1），柠檬酸钠（NaBZ）对BP123和P123的自组装行为的影响。相应地评估对疏水性药物辛伐他汀（SV）和体外药物释放行为的溶解。在NaCl或NaCa的存在下，浊点和临界胶束化浓度（CMC）降低，胶束变得更加疏水，胶束尺寸和药物溶解增加，药物释放速率减缓，纳卡的冲击比NaCl更大。相反，浊点和CMC随着NABZ的增加而增加。 NABZ可以通过疏水芳环参与形成胶束，这大大提高了SV的溶解。此外，由于BP123中加入到BP123或P123中加入到BP123或P123中，发生了不同的性能，这突出地增强了与疏水性药物的相互作用，导致BP123的药物释放的明显延迟。这项工作有利于在不同的药物应用中和药物递送系统中转动共聚物性能作为药物载体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号