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首页> 外文期刊>Colloids and Surfaces, B. Biointerfaces >Development of an antibacterial nanobiomaterial for wound-care based on the absorption of AgNPs on the eggshell membrane
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Development of an antibacterial nanobiomaterial for wound-care based on the absorption of AgNPs on the eggshell membrane

机译：基于蛋壳膜对agnps的吸收的伤口保健抗菌纳米植物的研制

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To develop a promising antibacterial agent for wound-care dressing, a series of silver nanoparticles (AgNPs) and eggshell membrane (ESM) composites (AgNPs/ESM) were prepared. AgNPs were prepared using a chemical reduction method and their characteristics were determined. Various pH and processing time combinations were tested to find the optimal conditions for preparing AgNPs/ESM composites. To obtain the optimal nontoxic-level silver release, the AgNPs stock solution was diluted to 2 times, 4 times, 6 times, 8 times and 10 times with water and the concentration of silver released by the composites was also tested. All the prepared composites showed antibacterial activity, but the activity was the strongest when the stock AgNPs solution was diluted to four times (a concentration of silver was 2.41 mg/L). The addition of AgNPs changed the ESM from hydrophobic to hydrophilic by lowering the water contact angles from 105 degrees to 75 degrees, which is important for the wound-healing process. And the AgNPs/ESM composites had a higher surface area (159.08 m(2)/g) than the natural ESM (24.32 m(2)/g) and a suitable pore size (10.92 nm) as well, endowing with better absorption and antibacterial abilities. These findings suggested that the AgNPs/ESM composites are promising candidates for the development of antimicrobial agent for biomedical devices and therapeutic applications, such as wound-healing agent.
机译：为了开发伤口护理敷料的有前途抗菌剂，制备了一系列银纳米颗粒（AgNP）和蛋壳膜（ESM）复合材料（AgNPS / ESM）。使用化学还原方法制备AgNP，测定它们的特性。测试各种pH和处理时间组合以找到用于制备AGNPS / ESM复合材料的最佳条件。为了获得最佳的无毒水平银释放，将AgNPS储备溶液稀释至2次，4次，6倍，8次和10次，还测试复合材料释放的银浓度。所有制备的复合材料都显示出抗菌活性，但是当稀释物溶液稀释至四次（银浓度为2.41mg / L时，该活性最强。通过将105度降低到75度，加入AgNP将ESM从疏水中改变为亲水性，这对于伤口愈合过程很重要。并且AgNP / ESM复合材料具有比天然ESM更高的表面积（159.08m（2）/ g）（24.32米（2）/ g）和合适的孔径（10.92nm），并且赋予更好的吸收和抗菌能力。这些发现表明AgNP / ESM复合材料是对生物医学装置和治疗应用的抗微生物剂的开发的承诺候选者，例如伤口愈合剂。

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