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首页> 外文期刊>Clinical and experimental obstetrics and gynecology >Immunohistochemical expression of hormonal receptors, collagen, elastin, and proteoglycans in genuine urinary incontinence
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Immunohistochemical expression of hormonal receptors, collagen, elastin, and proteoglycans in genuine urinary incontinence

机译：荷尔蒙受体，胶原蛋白，弹性蛋白和蛋白多糖在真正尿失禁中的免疫组织化学表达

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摘要

Purpose: To study the expression of hormonal receptors, collagen, elastin, proteoglycans, and VIP in the vaginal wall of women with stress urinary incontinence (SUI). Materials and Methods: Fifty-eight specimens of the anterior vaginal wall (28 women with SUI) were processed by Ventana immunostaining method. Results: Both groups were compatible for age, BMI, and obstetric history. Positive ER-alpha and ER-beta immunoreaction was observed in 46.4% and 3.6% of SUI (43.3% and 33.3 % of controls) (p 0.05), respectively, and PR immunoreaction in 39.3% of SUI (46.7% of controls). Collagen I and III immunoreaction was observed in 28,6% and 21.4 % of SUI (30.% and 36.7% of controls), respectively, and elastin, decorin, and fibromodulin immunoreaction in 10.7 %, 10.7%, and 10.7% of SUI (50%, 33.3%, 33,.3% of controls) (p 0.05), respectively. VIP immunoreaction was observed in 7.1% of SUI (36.7% of controls). Conclusion: Immunoexpression of ER-beta, elastin, decorin, fibromodulin, and VIP was significantly lower in SUI than controls, showing that the ER-beta dependent re-modeling of the extracellular matrix of vaginal tissues is the main mechanism of SUI.
机译：目的：研究激素受体，胶原蛋白，弹性蛋白，蛋白花糖，和vip在患有压力尿失禁（SUI）的阴道壁中的表达。材料和方法：Ventana免疫染色方法处理58个前阴道壁（28名妇女）的前阴道壁（28名女性）。结果：两组均兼容年龄，BMI和产科史。在46.4％和3.6％的SUI（43.3％和33.3％的对照）（P <0.05）中，观察到阳性ER-α和ER-β免疫反应，以及39.3％的SUI（46.7％）的PR免疫反应）。在28,6％和21.4％的SUI（30.％和36.7％的对照组）中观察到胶原蛋白I和III免疫歧视，以及ELASTIN，DECORIN和纤维蛋白免疫素免疫反应10.7％，10.7％和10.7％的SUI （50％，33.3％，33,30％的对照）（P <0.05）分别。在7.1％的SUI（36.7％的对照）中观察到VIP免疫反应。结论：SUI的ER-β，弹性蛋白，装饰素，纤维素和VIP的免疫表达显着低于对照，表明阴道组织细胞外基质的ER-β依赖性再建模是SUI的主要机理。

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