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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure.
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Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure.

机译：咖啡因 - 草药Ephedra组合增加了休息能源支出，心率和血压。

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SUMMARY 1. The purpose of the present study was to determine whether the consumption of an acute dose of caffeine and Ma Huang increases resting energy expenditure (REE), heart rate (HR) and blood pressure (BP) over a 3 h period. 2. A randomized, double-blind cross-over study was performed evaluating the acute effects of caffeine (150 mg)/herbal ephedra (Ma Huang; 20 mg ephedra alkaloids) versus a placebo. A total of eight healthy subjects (four males and four females) with a mean (+/-SD) age of 23.4 +/- 0.8 years (mean ages for males and females: 25.3 +/- 0.7 and 22.0 +/- 0.7 years, respectively) and 22.5 +/- 3.1% body fat (15.7 +/- 1.2 and 27.6 +/- 3.5% body fat for males and females, respectively) were recruited to the study. Participants were moderate caffeine users (approximately 150-300 mg/day). 3. Subjects reported to the laboratory following a 12 h fast and 48 h of a caffeine-free diet. Resting energy expenditure was measured prior to supplementation and for 15 min every 30 min for 3 h following supplementation. Heart rate and BP were obtained every 15 min. Blood samples were obtained every 30 min following the measurement of REE and analysed for caffeine, ephedrine, free fatty acids and glucose. 4. By 3 h, HR was 22.7 +/- 5.5% higher (P < 0.05) than baseline for the caffeine/ephedra trial compared with 8.9 +/- 2.2% higher for the placebo grou. At 3 h, systolic BP was 9.1 +/- 2.2% higher (P < 0.05) than baseline for the caffeine/ephedra trial compared with only 1.9 +/- 2.9% different from baseline for the placebo trial. There was no effect of the caffeine/ephedra combination on diastolic BP. Resting energy expenditure during the last 30 min was 4.5 +/- 2.5% higher in the placebo trial and 10.7 +/- 2.5% higher (P < 0.05) in the caffeine/ephedra trial; REE was 8.5 +/- 2.0% higher (P < 0.05) in the caffeine/ephedra trial compared with the placebo trial. Free fatty acids increased over time in the placebo and caffeine/ephedra trials (from 0.5 +/- 0.05 to 0.63 +/- 0.05 mEq/L and from 0.48 +/- 0.06L to 0.8 +/- 0.05 mEq/L, respectively). 5. Caffeine and herbal ephedra, at doses of 150 mg and 20 mg (ephedrine), respectively, result in a significant elevation in REE, HR and BP. Although significant, the increase in energy expenditure is negligible in terms of weight loss.
机译：概述1.本研究的目的是确定急性剂量的咖啡因和MA Huang的消耗是否在3小时内增加了休息的能量消耗（REE），心率（HR）和血压（BP）。 2.进行随机的双盲交叉研究，评价咖啡因（150mg）/草药麻黄（Ma Huang; 20mg Ephedra生物碱）与安慰剂的急性作用。共有八个健康受试者（四个男性和四个女性），平均（+/- SD）年龄为23.4岁+/- 0.8岁（男性和女性的平均年龄：25.3 +/- 0.7和22.0 +/- 0.7岁分别招募了22.5 +/- 3.1％的体脂（分别为男性和女性的15.7 +/- 1.2和27.6 +/- 3.5％）。参与者是中等咖啡因的用户（约150-300毫克/天）。 3.在速度12小时和48小时后向实验室报告的受试者在无咖啡因饮食中。在补充剂之前每30分钟恢复休息能量支出，每30分钟持续15分钟。每15分钟获得心率和BP。在测量REE后每30分钟获得血液样品，并分析咖啡因，麻黄碱，游离脂肪酸和葡萄糖。 4. 3小时，人力资源高于22.7 +/- 5.5％（P <0.05），比咖啡因/麻菌试验的基线与安慰剂GROU的8.9 +/- 2.2％相比。在3小时，收缩压BP比咖啡因/麻黄试验的基线为9.1 +/- 2.2％（P <0.05），而与安慰剂试验的基线仅为1.9 +/- 2.9％。咖啡因/麻菌组合对舒张压性BP没有作用。在过去30分钟期间，安慰剂试验中休息的能源支出为4.5 +/- 2.5％，在咖啡因/麻黄的试验中获得10.7 +/- 2.5％（P <0.05）;与安慰剂试验相比，REE在咖啡因/麻黄试验中较高（P <0.05）的较高（P <0.05）。安慰剂和咖啡因/麻黄试验中的游离脂肪酸随着时间的推移而增加（从0.5 +/- 0.05至0.63 +/- 0.05 meq / L分别为0.8 +/- 0.05 meq / L） 。 5.咖啡因和草药麻黄，分别为150毫克和20毫克（麻黄碱），导致REE，HR和BP的显着高度。虽然重要的是，在减肥方面的能量支出的增加可以忽略不计。

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