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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life
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Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life

机译：在王国范围内发现的水素离子渠道的基本结构和功能性质

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Summary Aquaporin ( AQP ) channels in the major intrinsic protein ( MIP ) family are known to facilitate transmembrane water fluxes in prokaryotes and eukaryotes. Some classes of AQP s also conduct ions, glycerol, urea, CO 2 , nitric oxide, and other small solutes. Ion channel activity has been demonstrated for mammalian AQP s 0, 1, 6, Drosophila Big Brain ( BIB ), soybean nodulin 26, and rockcress At PIP 2;1. More classes are likely to be discovered. Newly identified blockers are providing essential tools for establishing physiological roles of some of the AQP dual water and ion channels. For example, the arylsulfonamide AqB011 which selectively blocks the central ion pore of mammalian AQP 1 has been shown to impair migration of HT 29 colon cancer cells. Traditional herbal medicines are sources of selective AQP 1 inhibitors that also slow cancer cell migration. The finding that plant At PIP 2;1 expressed in root epidermal cells mediates an ion conductance regulated by calcium and protons provided insight into molecular mechanisms of environmental stress responses. Expression of lens MIP ( AQP 0) is essential for maintaining the structure, integrity and transparency of the lens, and Drosophila BIB contributes to neurogenic signalling pathways to control the developmental fate of fly neuroblast cells; however, the ion channel roles remain to be defined for MIP and BIB . A broader portfolio of pharmacological agents is needed to investigate diverse AQP ion channel functions in situ. Understanding the dual water and ion channel roles of AQP s could inform the development of novel agents for rational interventions in diverse challenges from agriculture to human health.
机译：综述主要内在蛋白质（MIP）系列中的水通道蛋白（AQP）通道旨在促进原核生物和真核生物中的跨膜水通量。某些类别的AQP S也导致离子，甘油，尿素，CO 2，一氧化氮等小溶质。对哺乳动物AQP S 0,1,6，果蝇大脑（围兜），大豆果糖蛋白26和PIP 2的岩石已经证明了离子通道活性; 1。可能会发现更多课程。新发现的阻止者正在提供用于建立一些AQP双水和离子通道的生理作用的基本工具。例如，选择性地阻断哺乳动物AQP1的中央离子孔的芳基磺酰胺AQB011已经显示出HT 29结肠癌细胞的迁移。传统的草药是选择性AQP 1抑制剂的来源，也是癌细胞迁移慢的抑制剂。在根表皮细胞中表达的植物在根表皮细胞中的发现介导通过钙和质子的离子传导，提供了洞察环境应激反应的分子机制。透镜MIP（AQP 0）的表达对于维持镜片的结构，完整性和透明度，果蝇BIB是必不可及的神经源性信号途径，以控制飞神经细胞的发育命运;然而，离子通道角色仍然是用于MIP和围兜的定义。需要更广泛的药理药物组合来研究不同的AQP离子通道功能。了解AQP S的双水和离子渠道作用可以在农业到人类健康的各种挑战中提供新的新药的发展。

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