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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Ptrf Ptrf transgenic mice exhibit obesity and fatty liver
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Ptrf Ptrf transgenic mice exhibit obesity and fatty liver

机译：ptrf ptrf转基因小鼠表现出肥胖症和脂肪肝

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摘要

Summary Polymerase I and transcript release factor ( Ptrf , also known as Cavin1 ) is an essential component in the biogenesis and function of caveolae. Ptrf knockout mice or patients with PTRF mutations exhibit numerous pathologies including markedly aberrant fuel metabolism, lipodystrophy and muscular dystrophy. In this study, we generated Ptrf transgenic mice to explore its function in vivo . Compared with wild‐type ( WT ) mice, we found that the Ptrf transgenic mice showed obesity with an increased level of ALT (alanine aminotransferase) and AST (aspartate transaminase). Ptrf transgenic mice exhibited severe fat degeneration and a higher degree of fat accumulation in the liver compared with WT mice. Consistently, we found that the expression of the fat synthesis gene, Fasn , was increased in the liver of Ptrf transgenic mice. Thus, Ptrf transgenic mice would be a good model for investigating the molecular mechanism and therapeutic targets of obesity and fatty liver associated diseases.
机译：发明内容聚合酶I和转录物释放因子（PTRF，也称为CAVIN1）是Caveolae生物发生和功能的必要组分。 PTRF敲除小鼠或PTRF突变患者表现出许多病理学，包括明显异常的燃料代谢，脂肪职业和肌营养不良症。在这项研究中，我们产生了PTRF转基因小鼠以探索其在体内的功能。与野生型（WT）小鼠相比，我们发现PTRF转基因小鼠表现出肥胖症，其含量增加（丙氨酸氨基转移酶）和AST（天冬氨酸转氨酶）。与WT小鼠相比，PTRF转基因小鼠在肝脏中表现出严重的脂肪变性和更高程度的脂肪积累。始终如一地发现，在PTRF转基因小鼠的肝脏中增加了脂肪合成基因FASN的表达。因此，PTRF转基因小鼠是研究肥胖和脂肪肝相关疾病的分子机制和治疗靶标的良好模型。

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    Li Qian; Bai Lin; Shi Guiying; Zhang Lianfeng; Dai Yifan; Liu Pingsheng; Cong Yu‐Sheng; Wang Miao;

  • 作者单位

    Institute of Aging ResearchHangzhou Normal University School of MedicineHangzhou China;

    Key Laboratory of Human Disease Comparative Medicine of the Ministry of HealthPeking Union Medical;

    Key Laboratory of Human Disease Comparative Medicine of the Ministry of HealthPeking Union Medical;

    Key Laboratory of Human Disease Comparative Medicine of the Ministry of HealthPeking Union Medical;

    Center of Metabolic Disease ResearchNanjing Medical UniversityNanjing China;

    National Laboratory of BiomacromoleculesChinese Academy of SciencesBeijing China;

    Institute of Aging ResearchHangzhou Normal University School of MedicineHangzhou China;

    Institute of Aging ResearchHangzhou Normal University School of MedicineHangzhou China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Fasn; fatty liver; obesity; Ptrf;

    机译：Fasn;脂肪肝;肥胖;PTRF;

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