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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Non‐IgE‐mediated hypersensitivity induced by multivitamins containing Tween‐80
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Non‐IgE‐mediated hypersensitivity induced by multivitamins containing Tween‐80

机译：由含有Tween-80的多种维生素诱导的非IgE介导的过敏率

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Abstract Multivitamins have been widely used for years. Adverse reactions, especially hypersensitivity, to multivitamins are becoming noteworthy. However, the classification of hypersensitivity is confusing, and the trigger is unknown. Multivitamins consist of two vials labelled vial 1 containing Tween‐80 and vial 2. Multivitamins without Tween‐80 were used as a contrast. Behaviouristics, histamine, IgE, and blood pressure of beagle dogs and guinea‐pigs were investigated by observation, ELISA and sphygmomanometer, and degranulation and apoptotic of RBL ‐2H3 cells were assayed by spectrophotometry and flow cytometry. The results showed that dogs suffered from multiorgan anaphylactoid symptoms, and dramatically decreased blood pressure, and high plasma concentrations of histamine after the first administration of multivitamins and multivitamins vial 1, which contains Tween‐80, compared to the control, multivitamins vial 2 or multivitamins without Tween‐80. In anaphylaxis assay, guinea‐pigs did not display any anaphylaxis symptoms and there were no changes in plasma histamine and IgE concentrations in the multivitamins and multivitamins vial 1 groups or in the multivitamins vial 2 and multivitamins without Tween‐80 groups except ovalbumin. Compared to the control, the release of β‐hexosaminidase and histamine, and the apoptosis of non‐antigen‐sensitized RBL ‐2H3 cells significantly increased in the Tween‐80 and multivitamins and multivitamins vial 1 groups in a concentration‐dependent manner. However, there was no alteration in multivitamins vial 2 and multivitamins without Tween‐80 groups. The results indicate that the hypersensitivity induced by multivitamins may be anaphylactoid reaction, but not anaphylaxis. Multivitamin‐induced release of inflammatory factors is triggered by Tween‐80 through a non‐IgE‐mediated pathway.
机译：摘要多年生多年来已被广泛使用。对多种维生素的不良反应，特别是超敏感性变得值得注意。然而，超敏反应的分类是令人困惑的，并且触发器未知。多种维生素由两个小瓶组成，标记为含有Tween-80和小瓶2的小瓶。没有吐温-80的多酰胺用作对比度。通过观察，ELISA和血压计研究了Beagle犬和豚鼠的行为性，组胺，IgE和血压，通过分光光度法和流式细胞术测定RBL -2H3细胞的脱粒和凋亡。结果表明，与对照，与对照，多种维生素小瓶2或多维生素相比，患者患有多态过敏症症状的血压，并显着降低了血压后的血压和含有补间-80的多种维生素的组胺浓度。没有吐温-80。在过敏反应测定中，几内亚猪没有显示任何过敏反应症状，并且多种维生素和多种维生素小瓶中的血浆组胺和IgE浓度没有变化，或者在多种维生素小瓶2中，除卵亮外，没有吐温-80组。与对照相比，β-六氨基氨基氨基酶和组胺的释放，以及非抗原敏化的RBL -2H3细胞的凋亡在舒适的依赖性方式中显着增加了吐温-80和多种维生素和多种维生素的小组1基团。然而，没有吐温-80组的多种维生素小瓶2和多种维生素没有改变。结果表明，多种维生素诱导的超敏反应可以是过敏反应反应，但不含过敏反应。多酰胺诱导的炎症因子的释放通过Tween-80通过非IgE介导的途径触发。

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