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首页> 外文期刊>Clinical and experimental pharmacology & physiology >High expression of DLG DLG 3 is associated with decreased survival from breast cancer
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High expression of DLG DLG 3 is associated with decreased survival from breast cancer

机译：DLG DLG 3的高表达与乳腺癌的存活率降低有关

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摘要

Abstract Abnormal expression or activity of proteins that regulate cell polarity can contribute to tumour progression. Discs large homolog ( DLG ) proteins play crucial roles in the maintenance of cell polarity and tissue morphogenesis. Previous studies of breast cancer patients showed that DLG 3 had greater expression in the cancerous tissues than non‐cancerous tissues, but the relationship between DLG 3 expression and breast cancer progression and prognosis is not clear. Here, we investigated the association of DLG 3 expression with breast cancer progression and prognosis using data on clinicopathological parameters from The Cancer Genome Atlas ( TCGA ) database, with different clinicopathological parameters using ualcan and LinkedOmics , and with different stages and subtypes using immunohistochemical staining. The results indicated greater DLG 3 expression in cancerous breast tissues than normal breast tissues and in luminal and Her2+ subtypes than in the triple‐negative subtype. DLG 3 expression also had a positive correlation with pathologic stage and decreased survival rate. Our data suggest that DLG 3 should be considered as a new diagnostic and prognostic biomarker for breast cancer.
机译：摘要调节细胞极性的蛋白质的异常表达或活性可以有助于肿瘤进展。光盘大同源物（DLG）蛋白在维持细胞极性和组织形态发生中起重要作用。以前对乳腺癌患者的研究表明，DLG 3在癌组织中具有更大的表达，而不是非癌组织，但DLG 3表达和乳腺癌进展之间的关系尚不清楚。在这里，我们研究了DLG 3表达与乳腺癌进展和预后使用来自癌症基因组（TCGA）数据库的临床病理学参数的数据，使用乌尔匹纳霉菌和母链组种，以及使用免疫组化染色的不同阶段和亚型的不同临床病理参数。结果表明，癌性乳腺组织中的DLG 3表达大于正常乳腺组织和腔和HER2 +亚型而不是三阴性亚型。 DLG 3表达还与病理阶段的正相关性并降低了存活率。我们的数据表明，DLG 3应被视为乳腺癌的新诊断和预后生物标志物。

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  • 作者

    Liu Jie; Li Pingping; Wang Ruiqi; Li Juan; Zhang Miao; Song Zhangjun; Liu Peijun;

  • 作者单位

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

    Mammary DepartmentTumour Hospital of Shaanxi ProvinceXi'an China;

    Center for Translational MedicineThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    breast cancer; diagnosis; DLG 3; prognosis;

    机译：乳腺癌;诊断;DLG 3;预后;

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