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首页> 外文期刊>Biomacromolecules >Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications
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Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications

机译：使用姜黄素 - 环糊精合成银纳米粒子，该姜黄素加入伤口敷料应用中的细菌纤维素水凝胶中

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摘要

Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is wellknown as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanopartides using aqueous curcumin:hydroxypropyl-beta-cydodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, and Candida auris.
机译：由于高微生物生物测量和微生物抗性问题，慢性伤口常常顽固地治疗。银是一种广谱天然抗微生物剂，具有广泛的应用，延伸到专有伤口敷料。最近，银纳米颗粒在伤口管理中引起了注意力。在目前的研究中，使用天然还原剂，姜黄素完成纳米颗粒的绿色合成，姜黄素是作为伤口愈合剂良好的天然多酚化合物。通过环糊精中的微胶囊克服姜黄素的疏水性。本研究证明了使用含水姜黄素水溶液的制造，表征银纳米喹啉：羟丙基 - β-细胞糖蛋白复合物，将它们加载到具有湿伤口愈合性能的细菌纤维素水凝胶中。这些纳米颗粒加载的细菌纤维素水凝胶的特征在于伤口管理应用。除了高细胞组合性外，这些新型敷料还表现出针对三种常见的伤口感染致病微生物金黄色葡萄球菌，假单胞菌Aeruginosa和Candida Auris的抗菌活性。

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  • 来源
    《Biomacromolecules》 |2020年第5期|共10页
  • 作者

    Gupta Abhishek; Briffa Sophie M.; Swingler Sam; Gibson Hazel; Kannappan Vinodh; Adamus Grazyna; Kowalczuk Marek; Martin Claire; Radecka Iza;

  • 作者单位

    Univ Wolverhampton Fac Sci &

    Engn Sch Pharm Wolverhampton WV1 1LY England;

    Univ Birmingham Sch Geog Earth &

    Environm Sci Birmingham B15 2TT W Midlands England;

    Univ Wolverhampton Fac Sci &

    Engn Wolverhampton Sch Sci Wolverhampton WV1 1LY England;

    Univ Wolverhampton Fac Sci &

    Engn Res Inst Healthcare Sci Wolverhampton WV1 1LY England;

    Univ Wolverhampton Fac Sci &

    Engn Res Inst Healthcare Sci Wolverhampton WV1 1LY England;

    Polish Acad Sci Ctr Polymer &

    Carbon Mat PL-41819 Zabrze Poland;

    Polish Acad Sci Ctr Polymer &

    Carbon Mat PL-41819 Zabrze Poland;

    Univ Worcester Sch Sci &

    Environm Dept Biol Sci Worcester WR1 3AS England;

    Univ Wolverhampton Fac Sci &

    Engn Res Inst Healthcare Sci Wolverhampton WV1 1LY England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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