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Severe asthma—A population study perspective

机译：严重的哮喘 - 人口研究视角

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Summary Background Severe asthma is a considerable challenge for patients, health‐care professionals and society. Few studies have estimated the prevalence of severe asthma according to modern definitions of which none based on a population study. Objective To describe characteristics and estimate the prevalence of severe asthma in a large adult population‐based asthma cohort followed for 10‐28?years. Methods N?=?1006 subjects with asthma participated in a follow‐up during 2012‐14, when 830 (mean age 59?years, 56% women) still had current asthma. Severe asthma was defined according to three internationally well‐known criteria: the ATS workshop definition from 2000 used in the US Severe Asthma Research Programme ( SARP ), the 2014 ATS / ERS Task force definition and the GINA 2017. All subjects with severe asthma according to any of these criteria were undergoing respiratory specialist care and were also contacted by telephone to verify treatment adherence. Results The prevalence of severe asthma according to the three definitions was 3.6% ( US SARP ), 4.8% ( ERS / ATS Taskforce), and 6.1% ( GINA ) among subjects with current asthma. Although all were using high ICS doses and other maintenance treatment, 90% did not have controlled asthma according to the asthma control test. Severe asthma was related to age 50?years, nasal polyposis, impaired lung function, sensitization to aspergillus, and tended to be more common in women. Further, neutrophils in blood significantly discriminated severe asthma from other asthma. Conclusions and Clinical Relevance Severe asthma differed significantly from other asthma in terms of demographic, clinical and inflammatory characteristics, results suggesting possibilities for improved treatment regimens of severe asthma. The prevalence of severe asthma in this asthma cohort was 4%‐6%, corresponding to approximately 0.5% of the general population.
机译：发明内容背景严重的哮喘对于患者，医疗保健专业人士和社会来说是一个相当大的挑战。根据现代定义，少数研究估计严重哮喘的患病率无非是人口研究。目的描述在大型成年人群哮喘队列中严重哮喘患者的特征和估算率为10-28岁的特征及估算严重哮喘的患病率。方法N？=？哮喘的1006名受试者在2012-14期间参加了随访，当时830（平均59岁？年，56％的女性）仍有目前的哮喘。根据三个国际知名标准定义严重的哮喘：2000年在美国严重哮喘研究计划（SARP）中的ATS研讨会定义，2014年ATS / ERS工作组定义和GINA 2017。所有具有严重哮喘的受试者对于任何这些标准正在进行呼吸专家护理，并通过电话联系，以验证治疗遵守。结果根据三种定义的严重哮喘的患病率为3.6％（美国SARP），4.8％（ERS / ATS任务费用），6.1％（GINA），受当前哮喘的受试者。虽然全部使用高IC剂量和其他维护处理，但GT; 90％没有根据哮喘控制试验控制哮喘。严重的哮喘与年龄＆ 50？年，鼻息肉，肺功能受损，对曲霉致敏，倾向于更常见的女性。此外，血液中的嗜中性粒细胞显着区别来自其他哮喘的严重哮喘。结论和临床相关性严重哮喘在人口统计学，临床和炎症特征方面与其他哮喘显着不同，结果表明治疗严重哮喘治疗方案的可能性。这种哮喘队列中严重哮喘的患病率为4％-6％，对应于一般人群的约0.5％。

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