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Dendritic cells in inflammatory sinonasal diseases

机译：炎症性Sinonasal疾病中的树突细胞

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摘要

Dendritic cells (DCs) are critical in linking the innate and adaptive immune responses, which have been implicated in the pathogenesis of many immune and inflammatory diseases as well as the development of tumours. The role of DCs in the pathophysiology of lung diseases has been widely studied. However, the phenotype, subset and function of DCs in upper airways under physiological or pathological conditions remain largely undefined. Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are two important upper airway diseases with a high worldwide prevalence. Aberrant innate and adaptive immune responses have been considered to play an important role in the pathogenesis of AR and CRS. To this end, understanding the function of DCs in shaping the immune responses in sinonasal mucosa is critical in exploring the pathogenic mechanisms underlying AR and CRS as well as in developing novel therapeutic strategies. This review summarizes the phenotype, subset, function and regulation of DCs in sinonasal mucosa, particularly in the setting of AR and CRS. Furthermore, this review discusses the perspectives for future research and potential clinical utility focusing on DC pathways in the context of AR and CRS.
机译：树突状细胞（DCS）对于将先天性和适应性免疫反应联系起来至关重要，这涉及许多免疫和炎性疾病的发病机制以及肿瘤的发育。 DCS在肺病病理生理学中的作用得到了广泛研究。然而，在生理或病理条件下，上呼吸道中的DC的表型，子集和功能在很大程度上是未定义的。过敏性鼻炎（AR）和慢性鼻窦炎（CRS）是两个重要的上呼吸道疾病，具有高普遍的患病率。异常先天和适应性免疫应答已被认为在AR和CRS的发病机制中发挥着重要作用。为此，了解DCS在Sinonasal Mucosa中的免疫应答在整理中的功能对于探索疾病和CRS的致病机制以及发展新的治疗策略至关重要。本综述总结了Sinonasal粘膜中DCS的表型，子集，功能和调节，特别是在AR和CR的设置中。此外，本综述讨论了未来研究和潜在临床公用事业的观点，专注于AR和CRS的背景下的DC路径。

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  • 作者

    Cao P. -P.; Shi L. -L.; Xu K.; Yao Y.; Liu Z.;

  • 作者单位

    Huazhong Univ Sci &

    Technol Tongji Med Coll Tongji Hosp Dept Otolaryngol Head &

    Neck Surg 1095;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Tongji Hosp Dept Otolaryngol Head &

    Neck Surg 1095;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Tongji Hosp Dept Otolaryngol Head &

    Neck Surg 1095;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Tongji Hosp Dept Otolaryngol Head &

    Neck Surg 1095;

    Huazhong Univ Sci &

    Technol Tongji Med Coll Tongji Hosp Dept Otolaryngol Head &

    Neck Surg 1095;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
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