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Immunoregulatory roles of eosinophils: a new look at a familiar cell.

机译:嗜酸性粒细胞的免疫调节作用:一种熟悉的细胞的新看。

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摘要

Eosinophils are usually considered as end-stage degranulating effector cells of innate immunity. However, accumulating evidence has revealed additional roles for eosinophils that are immunoregulatory in nature in both the adaptive and innate arms of immunity. Specifically, eosinophils have key immunoregulatory roles as professional antigen-presenting cells and as modulators of CD4(+) T cell, dendritic cell, B cell, mast cell, neutrophil, and basophil functions. This review addresses the emerging immunoregulatory roles of eosinophils with a focus on recent data that support this new paradigm. Recognizing both the effector and immunoregulatory functions of eosinophils will enable a fuller understanding of the roles of eosinophils in allergic airways inflammation and may be pertinent to therapies that target eosinophils both for their acute and ongoing immunomodulatory functions.
机译:嗜酸性粒细胞通常被认为是先天免疫的终末期脱钙效应细胞。 然而,积累的证据表明,嗜酸性粒细胞的额外作用是在免疫的适应性和先天武器中的自然性质中的免疫调节性。 具体地,嗜酸性粒细胞具有关键免疫调节作用作为专业抗原呈递细胞,作为CD4(+)T细胞,树突细胞,B细胞,肥大细胞,中性粒细胞和嗜碱性粒细胞功能的调节剂。 该审查涉及嗜酸性粒细胞的新出现免疫调节作用,重点关注最近支持这一新范式的数据。 识别嗜酸性粒细胞的效应和免疫调节功能将使嗜酸性粒细胞在过敏气道炎症中的作用更大了解,并且可能与靶向嗜酸性粒细胞的疗法术语患者患者急性和持续的免疫调节功能。

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