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Neuro-mediators as predictors of paediatric atopic dermatitis.

机译：神经调解器作为儿科特应性皮炎的预测因子。

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BACKGROUND: Attempts to identify predictors of atopic dermatitis (AD) have focused on genetic and immunologic factors. However, the role of neuro-mediators remains to be elucidated. OBJECTIVE: To evaluate nerve growth factor (NGF) and vaso-active intestinal peptide (VIP) in predicting paediatric AD and assess their correlation with intrinsic and extrinsic types of AD. METHODS: We performed a nested case-control study in the prospective Taiwan birth panel cohort study. Cord and maternal plasma and questionnaires were gathered at birth. During follow-up, we identified 40 available AD cases, which were matched to 80 unaffected controls chosen from this cohort. The concentrations of IgE, NGF, and VIP in cord and maternal plasma of these subjects were performed by ELISA. Receiver-operating characteristic (ROC) curves were generated to see how well each biomarker could predict AD. RESULTS: The NGF levels were significantly higher in AD patients than controls (mean+/-SD: 65.47+/-44.45 vs. 49.21+/-12.18 pg/mL for cord plasma and 89.68+/-41.04 vs. 66.96+/-23.05 pg/mL for maternal plasma) (P<0.05). VIP levels were also higher but not statistically significant. Plasma NGF may be a better biomarker than IgE in detecting paediatric AD (area under the ROC curve=0.65 vs. 0.61 for cord plasma and 0.69 vs. 0.61 for maternal plasma). Maternal NGF levels were significantly higher in patients with both intrinsic (96.18+/-48.15 pg/mL) and extrinsic (86.18+/-37.23 pg/mL) types of AD compared with controls (66.96+/-23.05 pg/mL) (P<0.05). We assessed a significant correlation between self-reported stress during pregnancy and maternal NGF levels (r=0.22, P=0.02). CONCLUSION: Our results suggest that NGF is a good alternative biomarker in predicting children with a risk of AD.
机译：背景：试图识别特应性皮炎（AD）的预测因子专注于遗传和免疫因素。然而，神经调解员的作用仍有待阐明。目的：评估神经生长因子（NGF）和血管活性肠肽（VIP）预测儿科广告，评估它们与内在和外在类型的相关性的相关性。方法：我们在预期台湾出生小组队列研究中进行了嵌套案例控制研究。在出生时聚集了脐带和母体等离子体和问卷。在随访期间，我们确定了40名可用的广告案件，其与从此队列中选择的80个不受影响的控件匹配。通过ELISA进行IgE，NGF和VIP的浓度和这些受试者的母体血浆的浓度。生成接收器操作特征（ROC）曲线，以了解每个生物标志物如何预测广告。结果：AD患者的NGF水平明显高于对照（平均值+/- SD：65.47 +/- 44.45与49.21 +/- 12.18 pg / ml，用于绳索等离子体和89.68 +/- 41.04与66.96 +/- 23.05 pg / ml用于母体血浆）（p <0.05）。 VIP水平也更高但没有统计学意义。血浆NGF可以是在检测儿科AD（ROC曲线下的面积= 0.65 Vs.0.61的区域下的脐带等离子体和0.69的母体血浆的0.69）中的更好的生物标志物。患者的母体NGF水平在内在（96.18 +/- 48.15 pg / ml）和外在（86.18 +/- 37.23 pg / ml）与对照组（66.96 +/- 23.05 pg / ml）的患者（86.18 +/- 37.23 pg / ml）类型（ P <0.05）。我们评估了妊娠期间自我报告的应激与母体NGF水平之间的显着相关性（R = 0.22，P = 0.02）。结论：我们的研究结果表明，NGF是一种良好的替代生物标志物，可以预测具有广告风险的儿童。

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