• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Clinical and immunological differences between asymptomatic HDM HDM ‐sensitized and HDM HDM ‐allergic rhinitis patients
【24h】

Clinical and immunological differences between asymptomatic HDM HDM ‐sensitized and HDM HDM ‐allergic rhinitis patients

机译：无症状HDM HDM-敏化和HDM HDM -Allergic鼻炎患者的临床和免疫差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary Background Confirmation of the clinical relevance of sensitisation is important for the diagnosis of allergic rhinitis. Objective To investigate the usefulness of an in vitro basophil activation test and component‐resolved diagnosis in distinguishing between symptomatic allergic rhinitis patients and asymptomatic sensitization to house dust mites ( HDM s). Methods Thirty‐six subjects with a positive skin prick test ( SPT ) for HDM were divided into a symptomatic (n?=?17) and an asymptomatic (n?=?19) group on the basis of their clinical history and a nasal provocation test. A basophil CD 63 response to in vitro stimulation with Dermatophagoides?pteronyssinus whole allergen extract and the IgE reactivity profiles for Der p 1, 2, 4, 5, 7, 10, 11, 14, 15, 18, 21, 23 were evaluated. Serum IgE and IgG specific to D?pteronyssinus whole allergen extract and total IgE were measured. Results There were no statistically significant differences in the levels of IgE (IgE levels were higher in symptomatic patients with P? = ? 0.055) and IgG specific to D?pteronyssinus and total IgE. Symptomatic patients showed a lower threshold for in vitro basophil activation (3.33?ng/ mL vs 33.3?ng/ mL ), a higher area under the curve ( AUC ) of basophil activation (171 vs 127) ( P? = ? 0.017), a higher response to positive control with anti‐Fcε RI stimulation (97% vs 79%) ( P? ? 0.001), a recognition of more HDM allergens (4 vs 2) and more frequent sensitization to rD er p 7 ( P?=? 0.016) and rD er p 23 compared to asymptomatic subjects ( P? = ? 0.018). There was a positive correlation ( r ?=?0.63; P? ? 0.001) between the number of recognized allergens and the AUC of basophil activation. Conclusion and Clinical Relevance In the subjects studied, the differences in the basophil response to D?pteronyssinus allergen extract, number of recognized HDM allergens and reactivity to rD er p 7 and rD er p 23 distinguish symptomatic from asymptomatic HDM sensitisation better than SPT or allergen extract‐specific IgE. Information regarding the clinical relevance of sensitization is important for the prescription of allergen‐specific immunotherapy.
机译：发明内容背景确认敏感性的临床相关性对于诊断过敏性鼻炎是重要的。目的探讨体外嗜碱性粒细胞激活试验和组分分辨诊断的有用性，以区分症状过敏性鼻炎患者及无症状敏感，以容纳灰尘螨（HDM S）。方法基于其临床历史和鼻挑衅，将HDM阳性皮肤刺刺试验（SPT）与阳性皮肤刺刺试验（SPT）进行分为症状（n？=α17）和无症状（n？=Δ19）组测试。嗜碱性CD 63对具有DermaTophagoides的体外刺激的乳碱刺激ΔPteronyssinus全部过敏原提取物和Der P 1,2,4,5,7,10,11,14,15,18,21,23的IgE反应性曲线。测量血清IgE和IgG特异于D？Pteronyssinus全部过敏原提取物和总IgE。结果IgE的水平没有统计学上显着的差异（症状患者的p？= 0.055）和IgG特异于D？Pteronyssinus和总IgE的IgG。症状患者在体外嗜碱性粒细胞激活（3.33Ω·Ng / ml Vs 33.3→Ng / ml），嗜碱性粒细胞激活的曲线（AUC）下的较高面积（171 Vs 127）（P？= 0.017），对抗FCεRI刺激的阳性对照的响应更高（97％Vs 79％）（p≤≤0.001），识别更多HDM过敏原（4 vs 2）和对RD ER P 7的更频繁敏感（P ？=Δ016）和与无症状受试者相比（p？= 0.018）相比。在公认的过敏原和嗜碱性粒细胞激活的AUC之间存在正相关（R？= 0.63;p≤0.63）。结论和临床相关性在研究的主题中，嗜碱性粒细胞反应对D？Pteronyssinus过敏原提取物的差异，公认的HDM过敏原和反应性与RD ER P 7和RD ER P2的反应性比SPT或过敏原更好地从无症状HDM敏化中区分症状。提取物特异性IgE。关于敏感性临床相关性的信息对于特异性免疫疗法的处方是重要的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号