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Drug–drug interactions and clinical considerations with co-administration of antiretrovirals and psychotropic drugs

机译：药物 - 药物相互作用和抗逆转录病毒和精神药物的临床考虑

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摘要

Psychotropic medications are frequently co-prescribed with antiretroviral therapy (ART), owing to a high prevalence of psychiatric illness within the population living with HIV, as well as a 7-fold increased risk of HIV infection among patients with psychiatric illness. While ART has been notoriously associated with a multitude of pharmacokinetic drug interactions involving the cytochrome P450 enzyme system, the magnitude and clinical impact of these interactions with psychotropics may range from negligible effects on plasma concentrations to life-threatening torsades de pointes or respiratory depression. This comprehensive review summarizes the currently available information regarding drug–drug interactions between antiretrovirals and pharmacologic agents utilized in the treatment of psychiatric disorders—antidepressants, stimulants, antipsychotics, anxiolytics, mood stabilizers, and treatments for opioid use disorder and alcohol use disorder—and provides recommendations for their management. Additionally, overlapping toxicities between antiretrovirals and the psychotropic classes are highlighted. Knowledge of the interaction and adverse effect potential of specific antiretrovirals and psychotropics will allow clinicians to make informed prescribing decisions to better promote the health and wellness of this high-risk population.
机译：由于艾滋病毒的人口中的精神疾病患病率高，并且精神疾病患者患者的艾滋病毒感染风险高，患有抗逆转录病毒治疗（ART）经常与抗逆转录病毒治疗（艺术）共同开放。虽然艺术令人惊奇地与涉及细胞色素P450酶系统的众多药代动力学药物相互作用，但这些与精神药物的相互作用的幅度和临床影响可能是对血浆浓度的可忽略效果，威胁到危及生命的扭曲或呼吸抑制。这种全面审查总结了关于抗逆转录病毒和药物剂之间的药物 - 药物和药物药物在治疗精神病患者 - 抗抑郁药，兴奋剂，抗精神病药，抗焦虑，情绪稳定剂和阿片类药物使用障碍和酒精使用障碍治疗中的药物 - 药物和药物药物之间的现有信息 - 并提供建议他们的管理层。另外，突出了抗逆转录病毒和精神课程之间的重叠毒性。了解特定抗逆转录病毒和精神药物的相互作用和不良影响潜力将使临床医生能够了解更好地促进这种高风险人群的健康和健康的决策。

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