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Are the ICD-10 or DSM-5 diagnostic systems able to define those who will benefit from treatment for depression?

机译：ICD-10或DSM-5诊断系统是否能够定义将受益于抑郁症治疗的人？

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Two widely used diagnostic systems, the International Statistical Classification of Diseases and Related Health Problems (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), are reviewed for their ability to define those who will benefit from active treatment rather than placebo. Both systems suffer from a weakness in defining symptoms sufficiently clearly to separate depression from normal mood variations in the general population. Consequently, normal individuals may be medicalized and defined as suffering from and treated for depression. Also, in mild depression, unlike moderate depression, a lack of significant separation of active treatment from placebo has been shown in individual double-blind, placebo-controlled studies and in meta-analyses of these treatment studies. Both systems would be more useful for treatment purposes if they provided a clearer symptomatic definition of moderate depression, as is widely used in pivotal regulatory standard efficacy studies.
机译：两种广泛使用的诊断系统，疾病和相关健康问题的国际统计分类（ICD-10）以及精神障碍的诊断和统计手册，第五版（DSM-5），审查了他们定义那些将受益的人的能力从积极的治疗而不是安慰剂。两种系统患有充分清晰地定义症状的弱点，以将抑郁从一般人群中的正常情绪变化分开。因此，可以用医学和定义正常的个体作为患有和治疗的抑郁症。此外，在温和的抑郁症中，与中度抑郁不同，在各个双盲，安慰剂对照研究和这些治疗研究中的荟萃分析中，缺乏显着分离安慰剂的活性治疗。如果他们提供了更清晰的中度抑郁症的症状定义，这两个系统都更有用，因为广泛用于关键调节标准疗效研究。

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