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Measurement of agitation and aggression in adult and aged neuropsychiatric patients: review of definitions and frequently used measurement scales

机译：测量成人和老年神经精神患者搅拌和侵蚀：定义审查和经常使用的测量尺度

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Agitation and aggression in adult psychiatric patients with psychoses and in persons with dementia increase the burden of disease and frequently cause hospitalization. The implementation of currently available management strategies and the development of new ones is hindered by inconsistent terminology that confuses agitation with aggression. This confusion is maintained by many rating scales that fail to distinguish between these two syndromes. We review the frequently used rating scales with a particular focus on their ability to separate agitation from aggression. Agitation and aggression are two different syndromes. For example, reactive aggression is often precipitated by rejection of care and may not be associated with agitation per se. We propose, in treatment studies of behavioral symptoms of dementia and challenging behaviors in psychoses, that outcomes should be evaluated separately for agitation and aggression. This is important for investigation of drug effectiveness since the medication may be effective against one syndrome but not the other. Separate assessments of agitation and aggression should be a general principle of trial design with particular salience for registration studies of medications proposed for approval by the U.S. Food and Drug Administration and other regulatory bodies.
机译：在成人精神病患者中搅拌和侵蚀患者和痴呆症的人，增加了疾病的负担，经常引起住院治疗。目前可用的管理策略的实施和新的管理战略的发展受到侵略骚动的不一致术语。这种混淆受到许多不区分这两个综合征的评级尺度保持。我们审查了经常使用的评级尺度，特别关注他们将激动激动的能力与侵略分开。激动和侵略是两种不同的综合征。例如，通过排斥护理通常沉淀活性侵蚀性，并且可能与搅拌本身无关。我们提出，在痴呆症的行为症状和精神上挑战性行为的治疗研究中，应单独评估结果以进行激动和侵略。这对药物效果的调查很重要，因为药物可能对一个综合征有效但不是另一个。单独的骚动和侵略评估应是试验设计的一般原则，特别是对美国食品和药物管理局和其他监管机构批准批准的药物注册研究的特定显着性。

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