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首页> 外文期刊>Acta paediatrica. Supplement >Control of congenital infection with Toxoplasma gondii by neonatal screening based on detection of specific immunoglobulin M antibodies eluted from phenylketonuria filter-paper blood-spot samples.
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Control of congenital infection with Toxoplasma gondii by neonatal screening based on detection of specific immunoglobulin M antibodies eluted from phenylketonuria filter-paper blood-spot samples.

机译：通过检测从苯丙酮尿症滤纸血斑样品中洗脱的特异性免疫球蛋白M抗体，通过新生儿筛查控制弓形虫的先天性感染。

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摘要

Two ongoing neonatal screening programmes for congenital infection with Toxoplasma gondii are presented. The New England Newborn Screening Programme has included congenital toxoplasmosis since 1986. The test is based on detection of Toxoplasma-specific immunoglobulin M (IgM) antibodies eluted from the phenylketonuria (PKU) card. The seroprevalence of Toxoplasma IgG antibodies is at present about 13% and the birth prevalence of congenital toxoplasmosis approximately 1 per 10000 liveborn children. The Danish national neonatal screening programme was expanded to include congenital toxoplasmosis from 1 January 1999. The test is also based on detection of Toxoplasma-specific IgM antibodies eluted from PKU cards. The seroprevalence of Toxoplasma IgG antibodies in pregnant women is around 25% and the birth prevalence about 1 per 3000 liveborn children. The birth prevalence of congenital Toxoplasma infection is within the range of other congenital disorders included in different screening programmes. Neonatal screening is feasible in areas with a low risk of congenital infection where prenatal screening will not be applicable.
机译：介绍了两个正在进行的针对弓形虫先天性感染的新生儿筛查程序。自1986年以来，新英格兰新生儿筛查计划就包括了先天性弓形虫病。该测试基于检测从苯丙酮尿症（PKU）卡洗脱的弓形虫特异性免疫球蛋白M（IgM）抗体。目前，弓形虫IgG抗体的血清阳性率约为13％，而每10000名活产儿中，先天性弓形虫病的出生率约为1。丹麦国家新生儿筛查计划从1999年1月1日起扩展到包括先天性弓形虫病。该测试还基于检测自PKU卡洗脱的弓形虫特异性IgM抗体。孕妇中的弓形虫IgG抗体血清阳性率约为25％，每3000名活产儿中的出生率约为1。先天性弓形虫感染的出生率在不同筛查程序中包括的其他先天性疾病范围内。新生儿筛查在先天性感染风险低的地区是可行的，这些地区无法进行产前筛查。

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