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Pregnancy outcome after cervical cone excision: a case-control study.

机译:宫颈锥切术后的妊娠结局:病例对照研究。

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摘要

BACKGROUND: To investigate the effect of cervical laser conisation (CLC) or loop electrosurgical excision procedure (LEEP) on the outcome of subsequent pregnancies. Methods. Multi-centre, retrospective, case-control study, which included a cohort of 742 women, who, after treatment with LEEP or CLC, gave birth or suffered second trimester miscarriage. Control women (n=742) were extracted from the respective hospital birth registries and matched by age and parity. Outcome measures were perinatal mortality, length of gestation, birth weight and preterm premature rupture of membranes (pPROM). RESULTS: There was no significant difference in perinatal mortality among women treated with LCL or LEEP compared to controls, 6/742 versus 2/742: odds ratio (OR)=3.1 (95% CI: 0.6-15.2). Excluding second trimester miscarriages, ORs for giving birth before week 37, 32 and 28 after conisation compared to the controls were 3.4 (95% CI: 2.3-5.1), 4.6 (95% CI: 1.7-12.5), and 12.4 (95% CI: 1.6-96.1), respectively, after adjusting for smoking habits during pregnancy, marital status and educational level. Adjusted ORs of birth weight <2,500, <1,500 and <1,000 g after conisation compared to controls were 3.9 (95% CI: 2.4-6.3), 4.4 (95% CI: 1.5-13.6), and 10.4 (95% CI: 1.3-82.2), respectively. The adjusted OR for pPROM was 10.5 (95% CI: 3.7-29.5). CONCLUSION: Treatment by CLC and LEEP increases the risk of preterm delivery, low birth weight and pPROM in subsequent pregnancies.
机译:背景:为了研究宫颈激光锥切术(CLC)或环形电外科切除程序(LEEP)对随后妊娠结局的影响。方法。一项多中心,回顾性病例对照研究,包括742名妇女,他们在接受LEEP或CLC治疗后分娩或早孕流产。从各个医院的出生登记处提取对照妇女(n = 742),并按年龄和性别进行匹配。结果指标为围产期死亡率,孕期,出生体重和胎膜早破(pPROM)。结果:与对照组相比,接受LCL或LEEP治疗的妇女的围产期死亡率无显着差异,优势比(OR)= 3.1(6/742对2/742)(95%CI:0.6-15.2)。排除妊娠中期流产,与对照组相比,在锥切后第37、32和28周之前分娩的OR分别为3.4(95%CI:2.3-5.1),4.6(95%CI:1.7-12.5)和12.4(95%) CI:1.6-96.1),分别针对怀孕期间的吸烟习惯,婚姻状况和教育程度进行了调整。与对照组相比,锥切后出生体重<2,500,<1,500和<1,000 g的调整后OR为3.9(95%CI:2.4-6.3),4.4(95%CI:1.5-13.6)和10.4(95%CI:1.3) -82.2)。 pPROM的调整后OR为10.5(95%CI:3.7-29.5)。结论:CLC和LEEP治疗增加了随后妊娠中早产,低出生体重和pPROM的风险。

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