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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Continuous use of oral contraceptives: An overview of effects and side-effects
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Continuous use of oral contraceptives: An overview of effects and side-effects

机译：连续使用口服避孕药：作用和副作用概述

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Objective. To describe the effects and side-effects of the continuous use of oral contraceptives. Design. A review of articles concerning oral contraceptives taken continuously or in cycles with hormones taken for more than 21 days per cycle. Methods. We searched publications in PubMed and Embase. Randomized controlled trials were selected if possible, otherwise case-control studies or cohort studies with controls were chosen. A level of evidence as described by the Centre for Evidence Based Medicine (Oxford University, Oxford, UK) was assigned to all selected studies. Main outcome measures. Clinical and paraclinical effects and side-effects of oral contraceptives administered continuously. Results. The studies suggest that the endometrium is inactive during continuous use of oral contraceptives and the risk of endometrial hyperplasia is not increased. Numbers of bleeding days are halved with continuous use; however, spotting and irregular bleeding are more often seen in the beginning of use, decreasing with time. Hemostatic parameters and serum lipid and carbohydrate profiles in continuous and conventional users do not differ. Menstrual cycle-related symptoms are relieved better by continuous treatment. After surgery for endometriosis, the effect of continuously used oral contraceptives on the risk of recurrence of pain has been found to be less than that of gonadotropin-releasing hormone (GnRH) analogues, but better than the rate seen during conventional cyclic use. Conclusion. Oral contraceptives taken continuously or in long cycles seem to offer benefits with regard to menstrual symptoms and the recurrence of symptoms related to endometriosis. Long-term studies, comprising large groups of women, are lacking.
机译：目的。描述持续使用口服避孕药的效果和副作用。设计。连续或循环服用口服避孕药的文章的评论，每个循环服用超过21天。方法。我们搜索了PubMed和Embase中的出版物。如果可能，选择随机对照试验，否则选择病例对照研究或有对照的队列研究。所有选定的研究均分配了循证医学中心（英国牛津牛津大学）描述的证据水平。主要观察指标。连续服用口服避孕药的临床和副临床作用及副作用。结果。研究表明，在连续使用口服避孕药期间子宫内膜不活跃，子宫内膜增生的风险并未增加。连续使用可使出血天数减少一半;但是，在开始使用时经常会出现斑点和不规则出血，并随时间减少。连续和常规使用者的止血参数以及血清脂质和碳水化合物谱无差异。持续治疗可以更好地缓解与月经周期相关的症状。子宫内膜异位症手术后，发现连续使用口服避孕药对疼痛复发风险的影响小于促性腺激素释放激素（GnRH）类似物，但优于常规循环使用期间的比率。结论。连续或长时间服用口服避孕药似乎对月经症状和子宫内膜异位相关症状的复发有好处。缺乏由大量妇女组成的长期研究。

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