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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >Comorbidity is an independent prognostic factor in women with uterine corpus cancer: A nationwide cohort study
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Comorbidity is an independent prognostic factor in women with uterine corpus cancer: A nationwide cohort study

机译：合并症是子宫体癌女性的独立预后因素：一项全国队列研究

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摘要

Objective To determine whether comorbidity independently affects overall survival in women with uterine corpus cancer. Design Cohort study. Setting Denmark. Study population A total of 4244 patients registered in the Danish Gynecologic Cancer database with uterine corpus cancer from 1 January 2005 until 13 October 2011. Methods All patients included in the study were assigned a comorbidity score according to the Charlson Comorbidity Index. Multivariate survival analyses were performed to investigate the prognostic impact of comorbidity adjusting for known prognostic factors. As performance status might capture the prognostic impact of comorbidity and because information on the variable grade was missing in some special histological subtypes, we included different models in the multivariate analyses with and without PS and grade, respectively. Main outcome measures Overall survival. Results Univariate survival analysis showed a significant (p < 0.001) negative association between increasing level of comorbidity and overall survival. Multivariate analyses adjusting for other prognostic factors showed that comorbidity is a significant independent prognostic factor with hazard ratios ranging from 1.27 to 1.42 in mild, 1.69 to 1.74 in moderate, and 1.72 to 2.48 in severe comorbidity. Performance status was independently associated to overall survival and was found to slightly reduce the prognostic impact of comorbidity. Conclusion Comorbidity is an independent prognostic factor in uterine corpus cancer and increasing levels of comorbidity are associated with shorter survival.
机译：目的确定合并症是否独立影响子宫体癌女性的总体生存。设计队列研究。设置丹麦。研究人群从2005年1月1日至2011年10月13日，在丹麦妇科癌症数据库中登记的共有4244例患有子宫体癌的患者。方法根据Charlson合并症指数，为研究中包括的所有患者分配合并症评分。进行多变量生存分析，以研究合并症调整已知预后因素对预后的影响。由于表现状态可能会捕获合并症的预后影响，并且由于某些特殊的组织学亚型中缺少有关可变等级的信息，因此我们在多变量分析中分别包括有和没有PS和等级的模型。主要结局指标总体生存率。结果单变量生存分析显示合并症水平与总体生存之间存在显着的负相关（p <0.001）。调整其他预后因素的多变量分析显示，合并症是一个重要的独立预后因素，轻度合并症的危险比范围为1.27至1.42，中度为1.69至1.74，重度合并症为1.72至2.48。表现状态与总体生存率独立相关，被发现会稍微降低合并症的预后影响。结论合并症是子宫体癌的独立预后因素，合并症水平升高与生存期缩短有关。

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