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首页> 外文期刊>Contact dermatitis >Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine
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Concomitant contact-allergic reactions to iodopropynyl butylcarbamate and iodine

机译：伴随碘丙炔基丁基氨基甲酸酯和碘的接触过敏反应

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Background: Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics, in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and the risk of subsequent iodine overdose. Objectives: To report on concomitant patch test reactions observed with iodine and IPBC in patients sensitized to iodine-containing antiseptics. Patients: Between 2012 and 2018, seven patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis caused by wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and/or povidone-iodine (PVP-I), which was considered to be relevant for their dermatitis. All patients were coincidentally also patch tested with IPBC. Results: All patients showed positive patch test reactions to several other allergens, including IPBC. No relevance could be detected for IPBC. Conclusions: We suspect that, notwithstanding the absence of firm evidence for IPBC being dehalogenated to produce free iodine in animals or in humans, the patch test reactions to IPBC in iodine-allergic subjects were possibly caused by free iodine released from this preservative agent, thus underlining the EU restrictions regarding the use of this preservative in cosmetics.
机译：背景技术碘丙烯基丁基氨基甲酸酯（IPBC）是一种广谱防腐剂，用于几种产品类型，包括化妆品，其中其浓度受到欧盟立法的限制，因为与其碘含量和释放有关，以及随后的碘的风险。过量。目的：报告用碘和IPBC观察到含碘防腐剂的碘和IPBC的伴随贴剂试验反应。患者：2012年和2018年间，七名患者，来自比利时的六名患者，来自法国的六个，两种患有急性皮炎的手术干预症，由伤口治疗引起的皮炎和来自职业皮炎的四个患者，并显示给碘和/或povidone-碘（pvp-i）被认为与皮炎相关。所有患者均匀地也与IPBC检测的贴片。结果：所有患者均显示出阳性贴剂测试反应，包括IPBC等几种其他过敏原。对于IPBC无法检测到相关性。结论：我们怀疑，尽管缺乏IPBC在动物或人类中生产自由碘的公司证据，但碘 - 过敏受试者中对IPBC的贴剂测试反应可能是由来自该防腐剂释放的游离碘引起的，因此强调关于在化妆品中使用这种防腐剂的欧盟限制。

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