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首页> 外文期刊>Contact dermatitis >Contact urticaria: Frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology; Network of Anaphylaxis; and Department of Dermatology, University Hospital Erlangen, Germany)
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Contact urticaria: Frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology; Network of Anaphylaxis; and Department of Dermatology, University Hospital Erlangen, Germany)

机译：联系Uricaria：三个队列中的频率，elicators和辅助因子（皮肤科的信息网络;过敏性网络;和皮肤科，大学医院Erlangen，德国）

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Abstract Background Contact urticaria (CU) is an infrequent, mostly occupational disease that may be life‐threatening (CU syndrome stage 4). Objectives To identify the current frequency, elicitors and cofactors of CU. Patients Three cohorts were retrospectively analysed for CU: (a) patients from the Information Network of Departments of Dermatology (IVDK) database (2000‐2014; n = 159?947); (b) patients from an allergy unit (Department of Dermatology, University Hospital Erlangen, 2000‐2015; n = 4741); and (c) patients from the Anaphylaxis Registry (2007‐2015: 6365 reported cases, including 2473 patients with Ring and Messmer grade III‐IV reactions) for severe cases with skin/mucosal manifestations occurring at the workplace vs cases not occurring at the workplace (n = 68 vs n = 1821). Results Four hundred and forty‐eight CU patients (0.28%) were diagnosed in the IVDK cohort, and 16 (0.34%) (10 of immunological aetiology, and 6 of non‐immunological aetiology) in the Erlangen cohort. The most frequent elicitors in the IVDK cohort were cosmetics, creams, sun protection agents (although these were less frequent in CU patients than in controls without CU; 26.8% vs 35.6%, P ??.0001), and gloves (significantly more frequent in CU patients than in controls; 18.1% vs 6.5%, P ??.0001). The most frequent elicitors in the Erlangen cohort were natural rubber latex and sorbic acid. Among the MOAHLFA index characteristics, in both cohorts occupational disease was more common in CU patients than in patients without CU. CU was significantly associated with allergic rhinitis and allergic asthma. Wet work was a relevant cofactor. In the Anaphylaxis Registry, 19 cases (0.3%) were identified with severe reactions including skin symptoms at the workplace linked to common occupational elicitors. Conclusions CU is a rare occupational skin manifestation with a frequency of 0.4% in the examined patients; it may, however, progress to anaphylaxis. Preventive measures are important, and should take into account the identified elicitors and cofactors.
机译：摘要背景联系荨麻疹（Cu）是一种不常见的，主要是职业病，可能是危及生命的（Cu综合征第4阶段）。目标识别Cu的当前频率，elictors和Cofactors。回顾性分析患者的三个队列：（a）来自皮肤科（IVDK）数据库信息网络（IVDK）数据库（2000-2014; n = 159？947）的患者; （b）来自过敏单元的患者（皮肤科，大学医院Erlangen，2000-2015; n = 4741）; （c）来自过敏反应登记处的患者（2007-2015：6365报告的病例，包括2473名患者，包括戒指和Messmer等级III-IV-IV反应的患者）对于在工作场所的工作场所的皮肤/粘膜表现出现的严重病例，而在工作场所不会发生（n = 68 vs n = 1821）。结果四百四十八名患者（0.28％）被诊断为IVDK队列，16例（0.34％）（0.34％）（10.34％）（10.34％）（10.34％）（10.34％）（10.34％）（10.34％）（10.34％）在Erlangen Cohort中的患者（10.34％）（10.34％）。 IVDK COHORT中最常见的优势是化妆品，乳霜，防晒剂（尽管这些含量少于CU患者的频率，而不是在没有CU的对照中; 26.8％Vs 35.6％，P？＆ 0001）和手套（显着在Cu患者中更常见于控制; 18.1％Vs 6.5％，p？＆ 0001）。 Erlangen Cohort中最常见的Elicitors是天然橡胶乳胶和山梨酸。在MoAHLFA指数特征中，在群组中，职业病在Cu患者中比没有Cu的患者更常见。 Cu与过敏性鼻炎和过敏性哮喘显着相关。湿工作是一个相关的辅助因子。在过敏反应注册表中，将19例（0.3％）鉴定出严重反应，包括与普通职业素质相关的工作场所的皮肤症状。结论Cu是罕见的职业皮肤表现，频率在检查的患者中具有频率;然而，它可以进展到过敏反应。预防措施很重要，应考虑到已识别的Elicitor和Cofactors。

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