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首页> 外文期刊>Behavioral neuroscience >Aged Rats With Intact Memory Show Distinctive Recruitment in Cortical Regions Relative to Young Adults in a Cue Mismatch Task
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Aged Rats With Intact Memory Show Distinctive Recruitment in Cortical Regions Relative to Young Adults in a Cue Mismatch Task

机译：具有完整记忆的老年大鼠在皮质地区相对于Cue Mismatch任务中的年轻成年人显示了鲜明的招募

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Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects, exhibiting a stable behavioral phenotype that may signal a resilience to memory decline. Increasing evidence from research on aging in the Long-Evans study population supports the existence of adaptive neural change rather than avoidance of detrimental effects of aging on the brain, indicating a malleability of brain function over the life span that may preserve optimal function. Augmenting prior work that centered on hippocampal function, the current study extends investigation to cortical regions functionally interconnected with the hippocampal formation, including medial temporal lobe cortices and posterior components of the default mode network. In response to an environmental manipulation that creates a mismatch in the expected cue orientation, aged rats with preserved memory show greater activation across an extended network of cortical regions as measured by immediate early gene expression. In contrast, young subjects, behaviorally similar to the aged rats in this study, show a more limited cortical response. This distinctive cortical recruitment in aged unimpaired rats, set against a background of comparable activation across hippocampal subregions, may represent adaptive cortical recruitment consistent with evidence in human studies of neurocognitive aging.
机译：与老年人一样，老年的长埃文斯大鼠在批判性依赖于内侧颞叶记忆系统的任务中表现出个性差异。虽然降低的记忆性能是常见的，但接近在这种脱离的啮齿动物群体中老鼠的一半表现在年轻受试者的范围内，表现出稳定的行为表型，这可能会向记忆衰退发出弹性。越来越多的证据来自长途学习人口中老龄化的证据支持适应性神经变化的存在，而不是避免老化对大脑的有害影响，表明脑功能的脑功能在可能保持最佳功能的寿命上。增强了以海马功能为中心的先前工作，目前的研究将调查延伸到用海马形成功能互连的皮质区域，包括默认模式网络的内侧颞叶皮质和后部部件。响应于在预期的提示取向中产生不匹配的环境操纵，具有保存记忆的老化大鼠显示通过立即早期基因表达测量的皮质区域的扩展网络中的更大激活。相比之下，年轻的受试者，与本研究中的老年大鼠相似，表现出更有限的皮质反应。这种独特的皮质招募在老年未受害大鼠中，针对海马次区域的可比激活的背景，可以代表适应性皮质招募，这与神经认知老化的人类研究有关。

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